Maryam Yousaf1, Naveed Shahzad2, Zeeshan Mutahir1 and Moazzam Ali1*
... sensitive (PC-3/Wt) and epirubicin resistant (PC-3/Res) prostate cancer cell lines were used in this study. Our data revealed that PC-3/Res cells had high expression of MRP-1 mRNA and protein in comparison with PC-3/Wt cells. MRP-1 was found distributed between intracellular and cell surface pools in PC-3/Res cells and was capable of drug efflux as shown by doxorubicin and epirubicin efflux assays. Moreover, qRT-PCR and Wes...
Sayra Tariq, Zeeshan Mutahir and Moazzam Ali*
...images. Anticancer drug, epirubicin was attached to the iron oxide nanoparticles. Immobilization of epirubicin on the nanoparticles was confirmed by FTIR analysis (Fourier-transform infrared spectroscopy). The spherical nanoparticles showed rapid pH sensitive drug release at pH 4.9 (pH of the cancer cell) targeting the tumor microenvironment and the cancer cell or endosomes/lysosomes. Drug loaded nanoparticles showed increas...
