Effect of Labetalol Combined with Nifedipine on the Efficacy, Renal Function and Hemodynamics of Hypertension in Pregnancy
Effect of Labetalol Combined with Nifedipine on the Efficacy, Renal Function and Hemodynamics of Hypertension in Pregnancy
Xia Huang1, Jin Guo2, Zhijun Fan1, Yue Xiao1, Lifang Li1 and Yuehua Luo1*
ABSTRACT
The objective of this study was to investigate the efficacy of labetalol in combination with nifedipine and its impact, renal function and hemodynamics of pregnancy-induced hypertension (PIH). The sample of ninety-eight patients diagnosed with PIH and treated at Shanghai East Hospital Ji-an Hospital between August 2018 and July 2019 were included in this study and randomly assigned to an observation group (OG, n=49) and a control group (CG, n=49) using the random number table method. Patients in the CG were treated with intravenous labetalol injection, and patients in the OG were treated with oral nifedipine on the basis of the CG. The clinical efficacy, renal function and hemodynamic level changes of the two groups were compared. Following the administration of the treatment, the OG exhibited a total effective rate (TER) of 81.63%, while the CG displayed a TER of 63.27%. Notably, a significant difference was observed between the two groups; after the treatment, the MAP level of patients in the OG was reduced than that before the treatment and better than that of the CG, and the levels of CI, SI and LCWI were increased than that before the treatment and better than the CG; the total incidence of adverse reactions in patients in the OG during and after the treatment was 10.20%, and that of patients in the CG was 26.53%. It was concluded that labetalol combined with nifedipine has obvious clinical efficacy in hypertension in pregnancy, which helps to further regulate renal function, improve hemodynamic level, and increase the rate of remission, and is worthy of clinical promotion.
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November 2024
Pakistan J. Zool., Vol. 56
