Haematological and Biochemical Indices of Neonatal Intrahepatic Cholestasis Caused by Alagille Syndrome
Haematological and Biochemical Indices of Neonatal Intrahepatic Cholestasis Caused by Alagille Syndrome
Liu Nie
ABSTRACT
The aim of this study was to determine the blood routine and biochemical indices of Alagille syndrome (ALGS) and to explore the changes of the indicators of neonatal intrahepatic cholestasis caused by ALGS. This study was conducted on data of thirty-two neonatal intrahepatic cholestasis caused by ALGS treated from June 2017 to January 2020 and were randomly selected as a study group (ALGS group). Thirty-six children with unexplained cholestasis in the same period were selected as a control group. The incidences of cardiovascular malformations, special faces, vertebral changes and ocular abnormalities in the ALGS group were greater than those in the control group before and after treatment (P<0.05). There was no significant difference in WBC, RBC and PLT count and absolute value of neutrophil (Neu) between two groups before and after treatment (P>0.05). The absolute value and percentage of Neu and the ratio of Neu to lymphn ocytes (LYM) in the ALGS group were raised compared to the control group before and after treatment (P<0.05). There was no significant difference in the levels of GOT, TG, HDL, and Alb between the two groups at before and after treatment (P>0.05). The levels of γ-GT, DBil, TBA, GPT, TC, LDL, TP and GLB in the ALGS group were raised compared to the control group at before and after treatment (P<0.05). The various clinical manifestations, haematological and biochemical changes are of great significance over time in judging neonatal intrahepatic cholestasis caused by ALGS.
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