Effect of Somatostatin Combined with Modified Dachengqi Decoction on Intestinal Function and Inflammatory Factors (TNF-α, IL-6, and IL-8) in Acute Pancreatitis
Effect of Somatostatin Combined with Modified Dachengqi Decoction on Intestinal Function and Inflammatory Factors (TNF-α, IL-6, and IL-8) in Acute Pancreatitis
Hong Sun and Jie Shao*
ABSTRACT
This article aimed to evaluate the effect of somatostatin combined with modified Dachengqi decoction on the improvement of intestinal function in patients with severe acute pancreatitis (SAP), and to explore its effect on the levels of inflammatory factors. Sixty patients with acute pancreatitis (AP) in the Department of Gastroenterology of Lin’an District First People’s Hospital from February 2021 to February 2023 were grouped: controls and experimental group, 30 cases in each group. The controls received somatostatin and conventional treatment, and the experimental group adopted modified Dachengqi decoction based on the controls. After treatment, the incidence of complications in experimental group was lower as against controls (P < 0.05). The duration of gastrointestinal symptoms and recovery time of gastrointestinal function in experimental group were shorter as against controls (P < 0.05). The level of amylase (AMS) in blood and urine of two groups decreased (P < 0.05), more clearly in experimental group (P < 0.05). The levels of serum inflammatory factors in two groups decreased (P < 0.05), more clearly in experimental group (P < 0.05). The therapeutic effect of experimental group was better as against controls (P < 0.05). Somatostatin plus modified Dachengqi decoction can reduce the incidence of complications, shorten the clinical recovery time, and is conducive to improving the curative effect, which is worthy of promotion.
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