Effects of Ginsenoside Rg3 on HLA-DR, HLA-ABC and Cellular Immune Function in Patients with Tumor Radiotherapy
Effects of Ginsenoside Rg3 on HLA-DR, HLA-ABC and Cellular Immune Function in Patients with Tumor Radiotherapy
Xiang Lv1, Sufang Zhang2, Li Ling3, Xian Wang4, Ying Xia5, Xiaoping Wang6 and Yan Li1*
ABSTRACT
The objective of this study was to study the effect of Ginsenoside Rg3 on HLA-DR, HLA-ABC and cellular immune function in patients with tumor radiotherapy. From July 2017 to August 2018, 80 patients who were diagnosed as tumor and received radiotherapy were randomly divided into Ginsenoside Rg3 group and control group. The lymphocyte increment rate, the expression rate of cell membrane surface molecules (HLA-DR, HLA-ABC, CD3, CD4, CD8) were measured by flow cytometry. The positive expression rates of lymphocyte antibodies (IgG, IgM) and Th1, Th2 cells were measured by ELISA. Compared with the control group, different doses of ginsenoside monomer Rg3 can significantly promote the proliferation of lymphocytes induced by LPS and Rg3. The expression of HLA-DR and HLA-ABC in Rg3 group was significantly higher than that in the control group, and the effect of middle dose Rg3 was the strongest. Compared with the control group, the expression of CD3, CD4 positive cells and the ratio of CD4+ / CD8+ in different doses of Rg3 were significantly up-regulated, and the expression of CD8 positive cells was down regulated. Different doses of Rg3 can significantly up regulate the expression of IgG and IgM antibody, down regulate the positive expression rate of Th2, and the middle and high doses of Rg3 can significantly up regulate the positive expression rate of Th1. Ginsenoside Rg3 can up regulate the expression of HLA-DR and HLA-ABC in peripheral blood lymphocytes of patients with tumor radiotherapy, and enhance the cellular immune function, which is worth further promotion in clinical application, and provide reference value for adjuvant treatment of patients with tumor radiotherapy.
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