Evaluation of Anxiolytic Effects of Plantago Major Leaf Extract in Male Albino Mice
Evaluation of Anxiolytic Effects of Plantago Major Leaf Extract in Male Albino Mice
Jingtao Gui1, Na Wang2 and Yanqiu Li3*
ABSTRACT
The present study aimed to investigate the effect of Plantago Major leaf extract (PMLE) on the anxiety level of laboratory mice. Forty male albino mice were divided into four groups three experimental groups and one control group each of 10 mice. The mice of the experimental groups were injected with three doses of 100, 200 and 300 mg/kg, and normal saline solution was injected intraperitoneally to the mice of the control group. To assess the level of anxiety, an elevated plus maze (EPM) device was used for 5 min. The standard indicators of anxiety assessment (number of entries and time spent in the open arm) were checked and recorded through observation. The results showed that PMLE in three doses of 100, 200 and 300 mg/kg, significantly increased the number of entries into the open arm (4.63±0.32, 5.37±0.41, 6.68±0.48) and the time spent in the open arm (53.1±3.88, 62.4 ± 2.61, 69.58 ± 2.02) compared to the control group (P<0.05). This study showed that PMLE can reduce the level of anxiety in mice.
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