Evaluation of Serum PAF, 1,25-(OH)2D3 and MMP-9 Levels in the Diagnosis of Kawasaki Disease and Prediction of the Risk of Coronary Artery Lesion
Evaluation of Serum PAF, 1,25-(OH)2D3 and MMP-9 Levels in the Diagnosis of Kawasaki Disease and Prediction of the Risk of Coronary Artery Lesion
Wei Li1, Hui Xu2, Si Li2 and Jing Liu2*
ABSTRACT
The objective of this study was to investigate the serum platelet activating factor (PAF), 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and matrix metalloproteinase-9 (MMP-9) levels in the diagnosis of Kawasaki disease (KD) and prediction of coronary artery lesion (CAL) value at risk. A total of 120 children with KD were selected as the KD group, and they were divided into acute stage group (n=64) and recovery stage group (n= 56), and another 60 healthy children were selected as the healthy control group. In addition, the KD group was divided into CAL group (n=48) and non-CAL group (n=72) according to the echocardiographic findings. The area under the receiver operating characteristic (ROC) curve (AUC) was used to compare the value of serum PAF, 1,25-(OH)2D3 and MMP-9 levels in diagnosing KD and predicting the risk of CAL. The levels of serum PAF and MMP-9 in the recovery group were raised than those in the healthy control group, and the levels of 1,25-(OH)2D3 were reduced than those in the healthy control group (P<0.05). Both were raised than the recovery period group and the healthy control group, and the level of 1,25-(OH)2D3 was reduced than the recovery period group and the healthy control group (P<0.05). The levels of serum PAF and MMP-9 in the CAL group were raised than those in the non-CAL group, and 1,25-(OH)2D3 level was reduced than that in the non-CAL group (P< 0.05). The AUC values of serum PAF, 1,25-(OH)2D3 and MMP-9 alone and in combination to diagnose KD were 0.807, 0.767, 0.834 and 0.867, respectively. The AUC values of serum PAF, 1,25-(OH)2D3 and MMP-9 alone and in combination to diagnose KD were 0.813, 0.758, 0.866 and 0.887, respectively. It was concluded that the changes of serum PAF, 1,25-(OH)2D3 and MMP-9 levels have a certain relationship with the degree of CAL in KD. It has high clinical application value in predicting the occurrence of CAL.
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