Histopathological Effect of Traces for Uranium on Cow Kidneys
Histopathological Effect of Traces for Uranium on Cow Kidneys
Oula E. Hadi*, E.H. Altaee
ABSTRACT
The pro-oxidant activity of uranium (U) is being evaluated in bovine kidneys, a tissue in which the toxic effects of this metal have been demonstrated. The study was conducted on several groups of grass-fed cows in different locations in Basra/Iraq. Histopathological examination of the kidneys revealed hemangiomatous transformation in cows with U in the kidney. Uranium levels were measured using a sodium iodide device, and samples were taken from the cows’ kidneys, as they are the organs most affected by uranium. It was noted that if low concentrations of uranium were taken, there would be inflammation in the tissues, and animal might die, leading to degeneration, necrosis, and inflammation. However, in high doses, it leads to the occurrence of various tumors in the kidneys or the occurrence of clear cell carcinoma, Sarcomatoid type of renal cell carcinoma. The results indicate that the levels of uranium found in grass lead to the depletion of the antioxidant defense system in cows and stimulate oxidative stress in the kidneys. Although at current uranium doses, restraint stressors have rarely shown additive adverse effects, their potential impact has not been underestimated.
Keywords | Histopathological effect of Uranium, Cell carcinoma, Necrosis, Inflammation
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November 2024
Vol. 12, Sp. Iss. 1
