Oviductus Ranae Improves Cognitive Disorder and Suppresses Oxidative Stress in Aging Mice by Activating Nrf2 Pathway
Oviductus Ranae Improves Cognitive Disorder and Suppresses Oxidative Stress in Aging Mice by Activating Nrf2 Pathway
Yuechen Li1, Yumo Li1, Xuefeng Zhuang1, Guangfu Lv2, Xiaowei Huang1, Zhe Lin1, Yuchen Wang1* and He Lin1*
ABSTRACT
Oviductus ranae (OR), the dried oviduct of mature female Rana dybowskii, also known as Hamayou and Hashimayou, is a famous animal derived traditional Chinese medicine that have a variety of pharmacological effects. In our study, the anti-aging effect of OR on 53-week-old aging mice was investigated. The results showed that OR could significantly shorten the destination quadrant distance and latency in the Morris water maze of aging mice. It obviously decreased the MDA, MAO-B and Lipo level in brain tissue, enhanced the SOD and GSH-Px activity in brain tissue, and increased the IgA, IgG, IL-1 and IL-2 level in serum. In addition, OR significantly improved the protein expressions of Nrf2, HO-1 and NOQ1 in the brain tissues of aging mice, which was detected by western blotting. In conclusion, OR treatment improved behavioral disorders and brain damage in the aging mice, suggesting that OR has the potential to be a new anti-aging drug candidate.
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