Protective Effect of Nicorandil Injection on Myocardial Damage in Patients with Acute ST-Elevation Myocardial Infarction
Protective Effect of Nicorandil Injection on Myocardial Damage in Patients with Acute ST-Elevation Myocardial Infarction
Fuyi Liu, Qian He, Luling Luo and Qiong Mu*
ABSTRACT
ST-elevation myocardial infarction (STEMI) is a serious cardiovascular disease. Nicorandil injection (NI) has the effect of dilating coronary artery and inhibiting calcium ion influx in myocardial cells, so it has a protective effect on myocardial damage (MD). The objective of this study was to protect NI on MD in STEMI patients. A retrospective analysis was conducted, including STEMI patients who met the inclusion criteria, and they were divided into Nicorandil group (NG) and control group (CG). The left ventricular end-systolic volume index (LVESVI), wall motion score index (WMSI), ejection fraction (EF), and clinical symptoms were compared between subjects adopting different methods following 6 weeks of intervention. The extent of myocardial infarction (MI), neutrophil lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), uric acid (UA), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) were analyzed. There were clear distinctions in LVESVI and WMSI between both groups. The area of MI was 14.81±4.31 percent in the NG and 18.57±4.72 in the CG, the distinction was apparent (t=-3.729). UA, NLR, and PLR in the NG were markedly lower as against the CG. The levels of IL-6, and hs-CRP in the NG were markedly better as against the CG. It was concluded that NI has an obvious protection on MD in STEMI patients, and can markedly inhibit the infarct size and inflammatory response level in patients with acute STEMI.
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