Association of Serum Inflammatory Factors and Hip Joint Scores with Adverse Prognosis After Internal Fixation in Patients with Femoral Neck Fractures
Association of Serum Inflammatory Factors and Hip Joint Scores with Adverse Prognosis After Internal Fixation in Patients with Femoral Neck Fractures
Hao Weng, Liang Zhu, Zhu Mei, Mingxian Wu and Qiang Xu*
ABSTRACT
The objective of this study was to explore the relationship between adverse postoperative outcomes, changes in serum inflammatory factor levels, and hip joint functional scores in patients undergoing internal fixation for femoral neck fractures (FNF). A total of 134 patients who underwent internal fixation surgery for FNFs were recruited. Based on their postoperative prognosis, patients were categorized into a control group (CG) (favorable FNF healing, n=100) and an observation group (OG) (non-union FNFs, n=34). Levels of interleukin (IL)-1, IL-6, IL-8, C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) were compared at preoperative (D0), postoperative day 1 (D1), postoperative day 7 (D7), postoperative month 1 (M1), postoperative month 3 (M3), and postoperative month 6 (M6). The Harris hip joint functional score was assessed preoperatively and 6 months postoperatively. At M1, M3, and M6, IL-1, IL-6, IL-8, CRP, and TNF-α levels were considerably elevated in the OG versus the CG (P<0.05). At 6 months postoperatively, the Harris total score increased in both groups, but the CG (86.94±5.06) had a greatly superior score to the OG (65.7±6.18) (P<0.05). Elevated levels of IL-1, IL-6, IL-8, CRP, and TNF-α along with decreased Harris hip joint functional scores following internal fixation surgery suggest the presence of adverse prognostic outcomes in FNFs.
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