Protective Effect of Shengdi-Cogongrass Decoction on Patients with Blood Heat Psoriasis
Protective Effect of Shengdi-Cogongrass Decoction on Patients with Blood Heat Psoriasis
Duo Yuan, Bin Shi and Yanhua Tu*
ABSTRACT
Shengdi-cogongrass decoction (SCD) is a traditional Chinese medicine formula, mainly composed of raw Rehmannia glutinosa (RG) and lalang grass rhizome (LGR). However, little is known about the molecular pharmacological activity of Shengdi-cogongrass on blood heat psoriasis (BHP). This study aims to explore the clinical and protective efficacy of SCD on interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in serum of patients with BHP. One hundred patients with blood fever psoriasis who were treated in our hospital from May 2020 to May 2023 randomly were selected as study subjects and included into an observation group (group SCD, n=50) and a control group (group CWM, n=50). The group CWM were treated with conventional western medicine, while the group SCD were treated with SCD. After one month, the clinical efficacy, IL-6 and TNF-α levels of the groups were compared. The results showed that the total effective rate was significantly higher in the group SCD than the group CWM (P<0.05). Moreover, the psoriasis area and severity index (PASI), four item itching questionnaire (FIIQ) scores, and the IL-6/TNF-α levels at 1 and 3 weeks of treatment were lower in the group SCD than the group CWM (P<0.05). The findings of this study support the protective effect of SCD in serum of patients with BHP through alleviating disease symptoms and reducing the expression level of inflammatory factors.
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