Bing Yan1, Meng Meng Zhang2, Xi Chen2, Yongming Li2*, Muhammad Khan3* and Tonghui Ma1*
...like phenotype (SCLP) of glioblastoma cells. ALT inhibited the growth, reduced mammosphere formation and down-regulated the expression of CSCs markers such as CD133, OCT4, SOX2, and NANOG in U87 and U251 glioblastoma cells in a dose-dependent manner. Further mechanistic study showed that ALT inhibits glioma SCLP and tumor growth through repression of EGFR/MOB1/LATS1/YAP signaling pathway. These findings were further validate...
Quratulain Amjad1,2 and Abdul Rauf Shakoori1,2*
...ation in lung cancer and glioblastoma cells whereas TGF-β is a well-described tumor inducer. The present study was aimed at deciphering the role of heparan sulphate in Slit2 mediated inhibition of cancer metastasis. Cancer proliferation was induced by TGF-β in lung cancer cells (H1650) and glioblastoma cells (SF767) and then the anti-proliferative role of Slit2 was analyzed in presence and absence of heparan sulfat...
