Guang-Xin E1, Yong-Ju Zhao1, Yue-Hui Ma2, Ming-Xing Chu2, Jia-Hua Zhang1, Zhong-Quan Zhao1, Hui-Jiang Gao2, Huai-Zhi Jiang3, Di Liu4, Li Liu5, Yan-Bin Zhu6, Wang-Dui Basang6, Luo-Bu Danjiu7, Tian-Wu An8, Xiao-Lin Luo8, Shi-Cheng He7 and Yong-Fu Huang1,*
...g pathway, and oxidative phosphorylation. The results of the present study confirmed that the selection of the dominant follicle involved the regulation of various physiological systems. These results provided helpful data to understand on the molecular mechanisms of dominant follicle selection in goats.
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Jie Yang
...kpoint cluster 2 through phosphorylation of extracellular-regulated kinase. The study validates miR-16 as a tumour suppressor gene in papillary thyroid cancer cells, and revealed a novel mechanism of miR-16-mediated apoptosis through extracellular-regulated kinase pathway.
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Yan Xu1, Jia Zhou1, Guangfu Lv2, Yuexin Liu1, Xintong Zhao1, Xin Li1, Doudan Ye2, Xiaobo Qu1,* and Xiaowei Huang1*
...ls and Smad2, Smad3, ERK phosphorylation levels. These results suggest that PAP can protect DOX-induced H9c2 damage by inhibiting the TGF-β / Smad / ERK signaling pathway.
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Muhammad Shahzad1, Arif Iqbal Umar1, Syed Hamad Shirazi1, Muhammad Tariq Pervez2*, Zakir Khan1, Waqas Yousaf1
HCDP: HEPATITIS C DATA BANK OF PAKISTAN
...Methylation, Ser/Tyr/Thr-phosphorylation, Methylation and ubiquitination sites in the protein sequences, motif/signature sub-sequences pattern, visual appearance of protein/nucleotide sequences for analysis of different sites, visual representation of multiple sequence alignments using colour code along with motif finding/conserved region in the sequence and analysing of graphical structure of phylogenetic tree. With the help of Format conv...
Yongyun Zhang1, 2, Xinyang Fan1, Fangting Zhou1, Weizhen Li3, Yina Ouyang1,4 and Yongwang Miao1*
...d p.115S were located at phosphorylation sites, which may lead to differences in the physicochemical properties of αS1-CN between buffalo and Bos genus.
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Lin Huang1, Ling Mai2, Keyan Zhong1 and Xinjun Chen3*
...ds (AA). It contained 10 phosphorylation sites and 7 post-translational modification sites. Both methods predicted that SeFABP contained 5 linear epitopes, and were highly coincident, indicating that SeFABP had good immunogenicity. Its secondary structure contains 2 α-helix (13.07%), 10 β-sheet (56.92%) and 30% random coli. The comparison of multiple FABPs sequences showed that the species were identical and highly conserved at multiple AA sites. Sp...
Fei Wang1, Xiaofen Hu1, Feng Wen2, Xiaoen Tang3, Shanshan Yang1, Shengwei Zhong1, Zuohong Zhou1, Xu Yuan1 and Yong Li1,*
...lycosylation site and 17 phosphorylation sites, and the secondary structure contains 50.76% of alpha helix, 5.30% of beta turn, 9.09% of extended strand, and 34.85% of random coil. Phylogenetic tree analysis shows that Wahui pigeon hold the close relative characteristics with chicken, turkey, and Taeniopygia guttata. Besides its conservative evolutional characteristic, the simple structure, subcellular localization, hydrophobicity and hydrophilicity indirectly...
Dong-Min Hou1, Ting Jia2, Hui-Juan Wang1, Zheng-Kun Wang1 and Wan-Long Zhu1*
...ly enriched in oxidative phosphorylation, steroid biosynthesis, glycerophospholipid and fatty acid metabolism pathways related to energy metabolism and lipid metabolism. Differentially expressed genes ND3, ND4, ND5, ND6, ND4L, CYTB, ATP8 and ATP6 in oxidative phosphorylation pathway were significantly up-regulated. Key genes related to lipid metabolism were identified as ELOVL6, ACACA, HSD17B12, SQLE, LSS, DHCR7, DHCR24, CYP...
Mohsin Shad1, Muhammad Usman2 and Qurratulann Afza Gardner1*
...g in defective oxidative phosphorylation and consequently effects other metabolic pathways. In the present article, we comprehensively compare the biodiversity of cyt b in bc1 and b6f complexes using in silico structural analysis tools, emphasizing that despite vast knowledge available in this field, still there are so much to explore about cyt b....
Ayesha Ahsan1, Rabia Arif2*, Samina Nazir1, Muhammad Saleem2 and Memunna G. Shahid1
... differentiation through phosphorylation and de-phosphorylation of other proteins. In this study, we have amplified PKC and beta tubulin homolog bml gene from six strains and F3 and F4 generations of Sordaria fimicola collected from the Evolution Canyon-1. Sequenced products of 464 bp of tubulin gene and 548 bp for PKC gene were aligned to observe the genetic variations between the eight parental strains of S. fimicola and r...
Zhe Lin1, Yumo Li1, Yuchen Wang1, Yuechen Li1, Ke Pei1, Guangfu Lv2, He Lin1* and Zhun Yu3*
...ne neurotransmitters and phosphorylation of p38 which closely related to anti-stress were examined. The results showed that, 203 potential OR targets and 126 stress-related gene targets were obtained, in which there were 15 common targets. Pathway enrichment analysis showed that there were 20 critical pathways. The results revealed that OR could increase the total swimming time, increase the survival time of enduring anoxia, and regulate monoamine neurotransmi...
Yisi Chen*, Jun Zhang and Fayin Li
...n 1h after incision. The phosphorylation level of GluN2b, p38MAPK, ERK, JNK and EPAC was measured by Western blot and immunofluorescence. We found that the mechanical pain induced by plantar incision peaked at 1h after surgery and lasted for 3 days. Compared with the isoflurane group, the mechanical pain in propofol group was significantly reduced within 2h after incision (P<0.05). In the propofol group, the phosphorylation
Yajuan Zheng, Qiuping Mo, Hongchao Tang, Qinghui Zheng and Dandan Guan*
.... Expression of LGR5 and phosphorylation ratio of IQGAP1 showed opposite trends in breast cancer and normal body. Viability, migration and invasion ability of breast cancer cells were all affected by LGR5 expression and IQGAP1 phosphorylation ratio. LGR5 affected IQGAP1 phosphorylation process by linking to IQGAP1 through its own C-terminus. This study proved that LGR5, which is highly exp...
Jie Wang1, Di Fang1, Jianqing Zhao1, Fei Huang2, Bo Liu2, Weikun Tao2, Baoshan Cui2 and Qinghua Gao1,2,3*
... pathways were oxidative phosphorylation and Wnt signaling pathway”,”MAPK signaling pathway “,” Regulation of actin cytoskeleton “and VEGF signaling pathway”. To conclude, these RNA-Seq results confirmed the differential expression of several genes in embryos of different genders during embryonic development. These DEGs partcipate in the transcriptional regulation of bovine embryonic development of different genders....
Wei Fang1,2,3, Jiawei Hong1,2,3,4, Zhengyi Fu1,2,3, Jing Hu1,2,3, Gang Yu1,2,3, Zhenhua Ma1,2,3* and Humin Zong5*
...ardiomyocytes, oxidative phosphorylation; The distribution types of SSR sites and their characteristic analysis results showed that the most important repeat type was mononucleotide repeats (7,840, accounting for 51.31%), followed by dinucleotide repeats (4,007, accounting for 26.22%), while the number of tetranucleotide, pentanucleotide and hexanucleotide repeat was relatively small. Through the above analysis, it could be concluded that the difference in gen...
Yanmei Wang1,2, Haoyun Li1, Lijuan Han1 and Wenkui Wang1*
...expression of cyclin D1, phosphorylation of Rb, and transcription function of E2F, thereby induced cell proliferation, caused pulmonary artery vascular remodeling, and lead to PH. This study aims to provide theoretical basis for finding new therapeutic targets for broiler PH....
Jinzhao Li1, Yawen Zhang2, Binghan Jia1, Yuqiong Zhao1, Huijuan Luo1, Xiaojie Ren1, Yuan Li3, Xiaoyan Bai1, Jing Ye3 and Junping Li1*
...relation between the tau phosphorylation and occurrence of OIC. The rat model of OIC was generated by intraperitoneal (i.p) injection of loperamide hydrochloride (Lop; 5mg/kg), and was evaluated by examining the fecal properties, intestinal propulsion mobility, immunohistochemistry (IHC), western blot (WB) and ELISA for detecting levels of Tau, P-Ser396-tau, P-Ser404-tau, protein kinase C (PKC), p38 MAPK (p38), p-p38 MAPK (p-p38) and µ-opioid receptors (...
Shumaila Usman1,2, Irfan Khan2, Kanwal Haneef3 and Asmat Salim2*
... that uncouple oxidative phosphorylation by decreasing ATP production. Cells treated with DNP were analyzed for the morphological changes and islet specific markers (MafA, Ngn3, Nkx 6.1, Pdx-1, insulin, glucagon, somatostatin and Sca-1) at gene and protein levels. In the presence of DNP, NIH3T3 cells appeared round, small and contracted while after reoxygenation they regained the normal fibroblast like spindle shaped morphology. The strategy to induce efficien...
Abrar ul Haq1, Shusheng Yin2, Amara Maryam1, Muhammad Khan1*, Hafiz Abdullah Shakir1, Muhammad Akhtar Ali3, Muhammad Irfan4, Muhammad Faisal Maqbool1 and Yongming Li2*
...ol did not inhibit STAT3 phosphorylation and dimerization. Moreover, we showed that lathyrol induces apoptosis as evident from a remarkably increased expression of cleaved caspase-3 in all four cancer cell lines. Taken together, our findings suggest that lathyrol is a potent STAT3 DNA binding domain inhibitor and exhibits a broadspectrum anticancer activity....
