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Rivaroxaban Reduces Cerebral Hemorrhage in Mice with TPA Ischemic Stroke after Thrombolysis by Down-Regulating PAR-1 and PAR-2

Sen Ye¹, Jiangang Pang² and Xiuli Wang³*

...e the mechanism by which rivaroxaban reduces cerebral hemorrhage in mice with TPA ischemic stroke after thrombolysis. Male Wistar mice (11-week-old) as our experimental subjects were administered with warfarin (0.2 mg/kg/day), rivaroxaban (60 mg/kg/day), rivaroxaban (120 mg/kg) /day), or solvent pretreatment for 14 d to induce transient middle cerebral artery occlusion for 90 min, followed...

Pakistan Journal of Zoology

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