Jonas Johansson Wensman1*a, Karl-Johan Leuchowius2,3 a, Jiting Yan1, Anna-Lena Berg4, Liv Bode5, Hanns Ludwig5, Sandor Belak6, Ulf Landegren2, Ola Soderberg2, Mikael Berg6
...rological and behavioral disorders in a wide range of mammalian animals, possibly including humans. Viral persistence in the brain has been frequently observed, however, the exact mechanisms behind BDV’s ability to establish persistence despite a prominent immune response are not known. Here we have used in situ proximity ligation assay (in situ PLA), a selective tool for studying virus-host protein-protein interactions. BDV P (phosphoprotein) and N (nuc...
Shazia Ali, Hizb Ullah and Sarwat Jahan*
...roup of hereditary blood disorders in which or absent beta globin chain synthesis, results in reduced Hemoglobin, decreased RBC production and anemia. Total 300 individuals were divided into 4 groups according to age and gender i.e ≤13 years females, >13 years females, ≤13 years and >13 years males. Height in centimeter, weight in kilogram was measured to calculate BMIKg/m2. Serum ferritin (ng/mL) and hemoglobin (gm/dl) alongwith ...
Muhammad Mansoor, Zaigham Abbas and Nageen Husssain*
...ciated with food related disorders and a number of autoimmune diseases. We hypothesized that gluten containing diet would further exacerbate an already undergoing arbitrary immune reaction in SLE patients. Pristane was injected in female BALB/c mice to induce the disease. After five months, mice in various groups were treated with prednisone and fed with gluten containing and standard diet for four weeks and applied procedure to detect minor changes in paw swe...
Rais Ahmed1,*, Khushi Muhammad1, Masood Rabbani1 and Muhammad Sarwar Khan2
...s and other reproductive disorders in animals and human beings. In this project, prevalence and distribution of soil borne Brucella species in nine districts of Punjab including Lahore, Faisalabad, Sheikhupura, Sargodha, D.G. Khan, Chakwal, Sahiwal, Gujranwala and Attock were determined. By using grid based sampling strategy, soil samples (n= 1280) were collected from villages (n=256, 5 samples/village) of the nine districts. Brucella genus speci...
Tahira Perveen1,*, Shaista Emad1, Saara Ahmad2, Zehra Batool1, Sarwat Yousuf1, Sheeza Sheikh1, Sara Qadeer1 and Saida Haider1
...treatment of psychiatric disorders. Along with the effectiveness these drugs are also associated with some side effects. Since ancient times herbs are used as medicinal purposes. One such herb is Fennel (Foeniculum vulgare). Fennel has many efficacious uses. It is a common herb and spice. It is used in many culinary purposes and also it has therapeutic purposes. In the present study antidepressant effects of fennel oil was monitored by comparing it with...
A. N. Naqvi and K. Fatima*
INCIDENCE OF LIVESTOCK DISEASES IN NOMAL AND NALTAR VALLEYS GILGIT, PAKISTAN
...th various diseases. The disorders reported in the area were digestive diseases, infections, mastitis, reproductive diseases, endoparasites, ectoparasites, wounds, hematuria, respiratory diseases, emaciation, hemorrhagic septic-emia, tumour, blue tongue, cow pox, enterotoxaemia, tetanus, paralysis and arthritis. In precise, endoparasites were found in 25.3% animals followed by respiratory diseases (24.74%). Most of the cattle (2053) and sheep (926) were found ...
Nazish Imran
...cents may lead to mental disorders with lifelong consequences, undermines compliance with health regimens and reduces the capacity of societies to be safe and productive”.(2) More than half of all mental disorders have an onset in childhood and adolescence with suicide being the third leading cause of death among adolescents.(1), (3)
Souheila Slimani1,*, Sonia Hamouda1, Chahrazed Souadi1, Sara Silini2, Cherif Abdennour2 and Leila Delimi3
...neurotoxic and fertility disorders. The objective of this work is to study the toxic effect of the dithiocarbamate “thiram 80% purity” on seasonal reproduction of male domestic pigeons Columba livia domestica, subjected to a long photoperiod (19L: 05D). The fungicide was orally administered at 5 and 10 mg/Kg body weight/day for 10 consecutive weeks.Testicular volume and weights were measured weekly, whereas semen quality, and histopathologic...
Sadaf Noveen1*, Shaista Habib Ullah2, Babar Alam3
...ildren with speech sound disorders, without any disability, and visiting various speech clinics in Pakistan. Test for Assessment of Articulation and Phonology in Urdu (TAAPU) was applied as it contains both oral motor screen and articulation tests.
Results: The study examined the relationship between Oral Motor Mechanism (OMM) and Articulation Disorders. Oral motor screening of 140 children showed that (23...
Rana Khurram Aftab1*, Farhat Ijaz2, Samia Jawed3
...erweight and obesity are disorders of balance of energy affecting people of various ethnic groups, age and socio–economic statuses. It has been found that obesity is closely associated and correlated with hypertension. Preventive strategies for obesity may offer a cost-effective approach towards lowering blood pressure.
Objectives: To determine the frequency of obesity according to body mass index and waist hip ratio and its relationsh...
Saiqa Andleeb* , Shaukat Ali
RNA interference; A tool for treatment of human diseases
...le now to treat numerous disorders. This review paper provides the basis for further development of RNAi technology as a drug therapy against various human disorders....
Anam Javed, Javed Iqbal Qazi*
Skin health implications of Chemical detergents and importance of biodetergents
...s a wide range of dermal disorders which are produced due to synthetic detergents. It has studied that ultimate solution of the grave issues, is common utilization of biosurfactants from domestic to industrial level. Biodetergents do not cause health complications, and as they are readily biodegradable so do not persist in environment. Our body’s protecting shield, the skin, has more chances of exposure and biodetergents have potential to eliminate the a...
Saman Fatima* and Shazia Iram
...currence of various skin disorders which leads to the rejection of fruit in international market. This study was designed in order to identify the pathogens that ruin the peal of Citrus reticulata Blanco (kinnow) in order to improve its quality. About twenty six sampled fruits of Citrus reticulata having damaged skin were obtained from the orchards of Sargodha. The samples were classified into groups on the basis of physical appearance of lesions on peal and t...
Syeda Ain-ul-Batool1, Sadia1, Kathrin Blasius2,3,4, Angela Kaindl2,3,4 and Ghazanfar Ali1,*
...cardiovascular and liver disorders. So far 21 genes are reported that cause BBS (BBS1-BBS21). A consanguineous family having clinical symptoms of BBS9 is described in current study. Mutation was detected in BBS9 on chromosome 7p14.3 using whole exome sequencing (WES). A splice acceptor site mutation (c.1131G>A) in exon 3 was revealed by Sanger sequencing.
...
Qudrat Ullah1,8,*, Huma Jamil1, Laeeq Akbar Lodhi1, Zafar Iqbal Qureshi1, Shakeeb Ullah1, Tariq Jamil2, Iahtasham Khan3, Shahbaz Bashir4, Qudratullah5, Inamullah Wazir6, M. Abdus Sallam1 and Muhammad Zubair7
...y of animal reproductive disorders was found to be significantly associated (P=0.0056) with seropositivity of the infection. Age, sex, parity, lactation and pregnancy status of the animal were not found significantly associated. Routine herd screening, consumtion of pasteurized milk and public awareness programmes would be helpful for control and prevention of zoonotic transmission.
... 
Hafiza Mehwish Iqbal1, Shahid Yousaf1, Salman Khurshid1*, Qurrat Ul Ain Akbar1, Saqib Arif1, Nasreen Fatima2 and Ali Murad Rahoo3
...ostharvest physiological disorders and organoleptic properties in relation to the occurrence of pathogenic diseases. Fruit samples (injured and healthy) were taken from the three different local markets of Karachi. Some of the fungal species viz. Aspergillus niger, Aspergillus flavus, Fusarium oxysporum, Rhizopus stolonifer and Alternaria alternata have been identified in citrus samples. However, major incidence was recorded for Aspergillus ni...
Muhammad Rehan3, Asim Aslam3, Javeria Umber4, Muti-ur-Rehman Khan3, Waqar Azeem3, Hassan Aftab5, Ahsan Anjum3, Muhammad Abid6, Abdul Hameed Khan3, Hafiz Hasnain Ayoub5, Altaf Hussain2 and Muhammad Farooq Khalid1*
...tions and non-infectious disorders. ...
Gasem Mohammad Abu-Taweel
...hemical and histological disorders were observed due to exposure to mercury via placenta during pregnancy and / or during lactation through weaning period. Overall, mercury chloride administration had direct influence on the social behavioural and blood parameters in the mice offsprings.
...
Rafia Sadaf1, Ishrat Younus2*, Sidra Maqbool2, Talha Bin Fayyaz3, Sarah Jameel Khan1, Sidra Siddique1 and Rida Fatima1
...lly been used in various disorders related to both male and female and proves a great remedy for ovaralgia, ovaritis, epididymitis, orchitis nervousness, sadness, mild restlessness and mental disorder. This investigation is designed to evaluate acute toxicity and anti-anxiety activity of ethanol extract of Pulsatilla nigricans leaves. The acute oral toxicity shows that, plant extract up to 5000 mg/kg produces no signs and symptoms related to toxicity an...
Jing Zhang1,2, Xin Wang2, Yun Zhao2, Yongcheng Jin2, Yongfeng Zhou2, Junmei Wang2, Yurong Fu2, Rui Wang2, Ruihua Li2, Hengtong Fang2 and Hao Yu2,*
...ction and mucosal immune disorders, the effect of zearalenone (ZEA) on intestinal mucosal function remains controversial. We aimed to explore the effects of short-term ZEA exposure on the mucosal barrier function in the colon. We found that the morphology of colonic mucosa in mice was normal after ZEA was administered by gavage for one week, the mRNA expression levels of mucosal Mucin-1, Mucin-2, regenerating islet-derived protein 3 gamma (Reg3γ), and tu...
Asmaa Abdallah Darwish
...-inflammatory postpartum disorders group). Blood samples were collected from all ewes and vitamins concentrations were estimated in all groups. The results of this work demonstrated a significant (P< 0.05) decrease in vitamin E, A, D3 and C concentrations in inflammatory diseases groups, late pregnant groups and postpartum groups. Conclusion: antioxidant hypovitaminosis partially participate in different ovine diseases pathogenesis and complications and the...
Ayesha Alam1,* and Labeeb Ali2
...s. Including respiratory disorders, bronchiolitis, digestive tract disorders, pneumonia and conjunctivitis. Additionally, traces of COVID-19 were also found in sewage water sources in some countries like Italy bringing attention towards analysis of sewage water. Based on information from cited literature it is estimated that an individual handling sewage water have approximately 1% chance of becoming infected with virus. Tre...
Sajid Ali1, Muhammad Avais1*, Aneela Zameer Durrani1, Kamran Ashraf2, Saira Jabeen1, Sajid Hameed3, Muhammad Awais1, Jawaria Ali Khan1 and Imtiaz Ahmad4
...igated for hoof and claw disorders based on clinical assessment. The prevalence of lameness at the herd-level ranged from 3.08% to 33.08% (overall = 14.20%). The prevalence based on severity showed that on all farms, the majority of cows were mildly lame (7.71%) followed in order by moderately lame (4.61%) and severely lame (1.88%). Prevalence of lameness was significantly higher (P<0.05) in cows with a low body condition score (≤2.75) than in cow...
Abd El-Hamid, M.I1; Seham, A. ElZeedy1; El-Sanousi A.A2, Reda, I.M2, Nehal, S. Saleh1., Abbas, A.M1
...rtion and nervous system disorders neonatal foal pneumonitis, highly contagious among susceptible horses, with viral Transmission to cohort animals occurring by inhalation of aerosols of virus-laden respiratory secretions. Extensive use of vaccines has not eliminated EHV infections, and the worldwide annual financial burden from these equine pathogens is immense. Clinical signs may occur despite the presence of a virus-specific immune response in the horse. Th...
Kanwal Haneef1,2, Rakhshinda Habib1,3, Nadia Naeem1,3 and Asmat Salim1,*
...: small;">Cardiovascular disorders are major cause of death globally. Regeneration of cardiac tissue with the use of stem cells has appeared as an effective cell-based therapeutic option. Mesenchymal stem cells (MSCs) are the potential candidates for cell therapy due to their ease of isolation, proliferation, anti-apoptotic and proangiogenic properties. MSCs have the ability to fuse with somatic cells in vivo and depending upon the microenvironment, the...
Ayesha Muzamil, Hafiz Muhammad Tahir, Shaukat Ali, Iram Liaqat, Aamir Ali, Muhammad Summer
...ed to treat inflammatory disorders. Theses synthetic drugs have many side effects on the health such as gastrointestinal problems, stomach ulcers, dizziness, liver or kidney problems etc. Cytokines play an important role in the induction and suppression of inflammation. Cytokines are diverse form of proteins that act pro- and anti-inflammatory cytokines. The main component of immunity is IL-1. IL-6 cytokine play its role in regulation of metabolic reactions. T...
Nabila Rasheed1*, Bushra Waseem1, Kanwal Haneef2, Shumaila Usman3, Madeeha Sadiq1, Tabinda Urooj1, Sarah Tarique2 and Dabeeran Zeha4
...tigation shows metabolic disorders are not only responsible for genetic problems and certain disease risk factors in adult life but also have adverse effects on perinatal environment. This study was designed for the comparative analysis of viability and healing properties of GDM affected WJMSCs (GDM-WJMSCs) with Normal controls (N- WJMSCs). Mesenchymal stromal cells were isolated from Wharton’s jelly of human umbilical cords from normal and gestational d...
Abdullah Abdo Albegali1, Tayyaba Aftab1, Atiq-ur-Rehman1*, Amir Rashid1 and Mayada Mohammad1,2
...tress and haematological disorders. This study was done in the investigation of antihyperlipidemic effects of methanol extract of seeds of this plant in hyperlipidaemia Wistar albino rats induced by Triton X-100. There were 4 groups of rats: Group A served as normal; Group B, C and D were given high cholesterol diet and administered with intraperitoneal injection of Triton X-100 to induce hyperlipidaemia. Group B was administered with distilled water and high ...
A.M. Abdul Azeem, Ashraf M. Mounir and Amr N. El-Shahat*
...that can reduce diabetic disorders....
Neven Waheeb1*, Sherif Marouf2, Essam Nasr3, Shaymaa Abdelmalek2
...e collected with gastric disorders. The presence of H. Pylori infection in stool and fecal samples were tested by ELISA and PCR methods. In ELISA the test utilizes H. pylori antibodies to selectively detect H. pylori Antigen in human stool and fasces of pet animals, and PCR by using 16srRNA primers through a semi-nested PCR technique.
Keywords | ELISA, PCR, 16srRNA
...
Nour El-Hoda Khayrat Hammad1*, Yousef Y. El-Seady3, Azza E. Hassan1, Sara T. Elazab2, Magdy S. Amer2
...nazole induced fertility disorders.
Keywords | Male fertility, Antifungal, Medicinal plant, Testosterone hormone, Aromatase
...
Alexander Tsybulsky1*, Tatyana Tabakaeva1, Anna Klimovich2, Michail Shchelkanov1, Eduard Kostetsky1, Maksim Aliev1, Anton Degtyarenko3
...kidneys and liver, whose disorders are most critical in the progression of the leukaemic process; 3) Replicative and expressive activity of provirus FeLV in blood white cells (WBC); 4) Concentration of the IFNs and viral p27-FeLV-specific antigen in the blood plasma; 5) Expression of ifnα6, ifnα7, ifnβ1, ifnγ and ifnλ1 genes in WBC; 6) Expression of p53 and gadd45g genes in WBC. The concentration of the viral p27-FeLV antigen in t...
Yuechen Li1, Yumo Li1, Xuefeng Zhuang1, Guangfu Lv2, Xiaowei Huang1, Zhe Lin1, Yuchen Wang1* and He Lin1*
...ment improved behavioral disorders and brain damage in the aging mice, suggesting that OR has the potential to be a new anti-aging drug candidate....
Juweria Abid1, Hooria Latif2, Amir Sohail2, Saroosh Fatima Tahir Syed2, Shakeel Ahmad3, Tooba Asif4 and Muhammad Farooq5*
...eater increase in eating disorders all around the world from the past fifty years specifically in the adolescents’ age group including psychological health i.e., excessive dieting, stress from educational and academic pressure which makes them susceptible to extreme malnourishment. The sample consisted of 450 university students aged 20 to 25 years. It was observed that majority of the students were day-scholars (59.8%) due to which their daily eating ro...
Rawda S. Mohamed1,2, Mohammed Y. Matoock2*, Abeer H. Abdelrazek2
... in several neurological disorders of human beings. Mice are frequently used in biomedical research, including stress research. However, mice respond differently to stress. Therefore, we conducted this study to screen the behavioral and biochemical responsiveness of two different strains of mice, Balb/c (B) and Swiss (S). A total of fourteen adult males, each of (S) and (B) mice, were housed in either the control group or the multiple concurrent acute stress (...
Dalia M. Aboelhassan1*, Inas S. Ghaly1, Noha E. Ibrahim2, Nermeen M. Shaffie3, Mariam G. Eshak1, Aboelfetoh M. Abdallah4, Ibrahim M. Farag1
...oxicity, causing various disorders to human and animal health. Hence, the present work is designed to investigate the capacity of Fagonia cretica extract (FCE) to inhibit bisphenol A-induced genotoxicity and histopathology in rats. In the genetic study, the assaying of expressions of IkBα and COX-1 genes in liver tissues, as well as the expressions of mdr1a and COX-1 genes in kidney tissues are evaluated. In addition, the histological architectures of th...
Atta Ullah*, Nasrullah Khan, Ataur Rahman and Rafi Ullah
...estinal, skin, and blood disorders ailments. In addition, we recommend the sustainable use of the flora to maintain the proper floristic composition in the studied site....
Abdullah Channo1*, Asmatullah Kaka1, Qudratullah Kalwar2, Imdadullah Jamali3, Ghulam Jelani2, Muhammad Bakhsh4, Ghulam Nabi Dahri5 and Jai Parkash Goil6
...ing so many reproductive disorders and cystic ovarian disease (COD) is one of the important disease which cause major economic losses to farmers. COD affects fertility of animal which is important to reproduce young ones, that occurs due to negative impact factors on hypothalamus-pituitary stalkand normal function of the ovarywhich leads to alteration in follicular development, ovulation, reduced reproductive performance, unsuccessful ovulation, increased inte...
Lyudmila Yakovlevna Rodionova*, Irina Valeryevna Sobol, Lyudmila Vladimirovna Donchenko, Artem Vasilevich Stepovoy and Andrey Georgievich Koshchaev
...ssociated with metabolic disorders.
...
Khaliq Dad1, Fenliang Zhao2, Rumsha Hassan3, Kainat Javed3, Humaira Nawaz4, Muhammad Usman Saleem5, Tahreem Fatima6 and Muhamad Nawaz3*
...causing acute or chronic disorders in the people of all ages. Similarly these pesticides cause serious threats to the aquatic ecosystem after their release by comprising different toxic substances, heavy metals and contaminants. This review paper has focused on the toxic nature of different pesticides, impacts and their possible refinement strategies from the environment as well as ways to minimize their impacts on plants and animals as adverse impacts of pest...
Mahmoud S. Sirag1*, Effat L. El Sayed2, Mahmoud M. Hussein3, Khalid A. El-Nesr1, Mahmoud B. El-Begawey1
...a result of reproductive disorders and immunosuppression. To identify the pathological alterations and Immunohistochemical localization and distribution of BVDV antigen in the genital organs of persistently infected and acutely infected cows, this study was carried out on genital organs of thirty cows submitted to slaughter houses suffering from reproductive disorders. Pathologically, three mummified fetuses had been extract...
Aysam Fayed1, Mohga A Ibrahem2, Soha A. Hassan3, Mohammed Abdalla Hussein4*, Tamer Roshdy1
...en obesity and metabolic disorders like Type 2 diabetes, cardiovascular disease, and several types of cancer has made obesity a challenge for world health. The current study’s objective was to assess the antioxidant capacity of cranberry extract in high-fat diet-induced obesity. For eight weeks, 36 white albino rats weighing 197±10 g were selected at random to five groups: Group I was administered a regular diet; Group II was fed a high-fat diet; ...
Saba Rashid*, Rehan Ashraf, Hafiza Faseeha Iftikhar, Zohaib Bilal Khan, Samreen Sanawar, Aamina Jamil, Misha Salam Bajwa, Manahil Riaz
...olved in canine movement disorders. In this consensus statement, standard terminology for describing the various movement disorders is recommended with an emphasis on paroxysmal dyskinesia, as well as a preliminary classification and clinical approach to reporting cases. In the clinical approach to movement disorders, we recommend categorizing movements into hyperkinetic vs hypokinetic, pa...
Muhammad Ikram Ullah
...tion of genes in complex disorders like alpha-mannosidosis....
Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5
...atment of cardiovascular disorders....
Aamir Mushtaq1*, Fatima Habib2, Umar Farooq Gohar3, Abdul Malik4 and Mobasher Ahmad2
...e treatment of different disorders. However, more scientific work is needed to explore its fetotoxicity and genotoxicity.
Novelty Statement | In this article, we contributed a new thing by providing scientific evidences regarding acute and chronic toxicity of Pimpinella anisum that P. anisum is free from the toxic. It can be used in food and medicines quite safely.
...
S.H.M. Faruk Siddiki1*, Md. Golam Morshed2, Md Robiul Karim1, Lutfun Naher1, Md. Sodrul Islam3
...ates (20.12%), digestive disorders (18.55%), gyneco-obstetrical diseases (4.37%), and surgical cases (3.06%) were recorded as major clinical problems, with other diseases having a prevalence of less than 1% for each. Among the ten categories, the prevalence of parasitic diseases, infectious diseases, general systemic states, and digestive disorders was significantly (P < 0.001) higher. The diseases were significantly (P &...
Zubair Ali, Muhammad Sohail*, Yasir Ameen, Hamidullah, Ishtiaq Ahmed and Mehwish Malik
...for various reproductive disorders, whereas 21% of cows were found normal. Overall occurrence of reproductive disorders was higher (52%) in multiparous cows (4th calver and above) followed by multiparous cows (2nd and 3rd calver) (26%) and the incidence was lowest (22%) in 1st calvers. The incidence was higher in Friesian Cross bred cows (36%) followed by Sahiwal cows (25%), Jersy Cross bred (22%) and lowest in non-descript ...
Hemayet Hossain1, Md. Masud Parvej1*, Khadiza Akter Brishty3, Muhammad Ali4, Junayed Ahmed4, Asibul Hasan4, Rubel Miah4, Md. Piplu Mia4, Saad Muhammad Rafe-Ush-Shan4, Md. Nazmul Alam4 and Md. Zahidul Islam Khan2
...-infectious diseases and disorders (IND) in ruminants throughout the year 2021 in Bangladesh. A total of 755 selected clinical cases were recorded, of which 450 were cattle and 305 were goats, respectively. The selected clinical cases were diagnosed through anamnesis, physical examination, clinical signs, gross pathology or postmortem examination, and clinical examination using common laboratory techniques. A total of 28 infectious and non-infectious diseases ...
Hanaa M. Abdelkhalek1, Hanan E. Nagib1, Randa S. Elias1, Saad S. Mansour1, Walid S. Mousa2*
...s involved in veterinary disorders including clinical mastitis in buffaloes. This study aimed to investigate the antibiogram pattern and synergistic effect of amikacin and norfloxacin against resistant P. aeruginosa isolates from mastitis origin. In addition, detection of some virulence and antibiotics resistance genes. Two hundred buffaloes were examined and sixty mastitis milk samples were collected from clinical cases from the period from October 2021 until...
Khitam J. Yahya*, Mohammed T. S. Al-Zubaidi
...causing gastrointestinal disorders in various hosts worldwide. The current study was undertaken to study the biology of Cryptosporidium meleagridis and examine the anti-Cryptosporidial efficacy of curcumin in experimentally infected quails compared with that of paromomycin. This study carries out from September 2022 to January 2023 in Baghdad city, Iraq. Oocysts were isolated from naturally infected quails identified as Cryptosporidium meleagridis and used as ...
Munir Ahmad1, Abdul Ghaffar1, Riaz Hussain2* and Rifat Ullah Khan3*
... physical and behavioral disorders were noted in terms of time and concentration manners. In comparison to control fish, the hematological profile including lymphocyte, hemoglobin erythrocyte and monocyte counts, was considerably (p < 0.05) lower. The final results on the serum biochemical parameters showed significantly (p < .05) higher concentrations of liver biochemical profile, biomarkers of kidneys, triglyceride, glucose, and cholesterol in fish tre...
Farheen Shafique1, Shaukat Ali2*, Mahreen ul Hassan3, Saiqa Andleeb1
... awareness about genetic disorders is not sufficient.
Novelty Statement | This manuscript presents the first knowledge assessment study on β-thalassemia in Azad Jammu and Kashmir, Pakistan. Our research contributes to the understanding of β-thalassemia in this region and highlights areas where educational interventions may be necessary. This study fills an important gap in knowledge and prov...
Amna Mushtaq, Asia Bibi* and Nahid Kausar
...(35.3% vs. 6.7%), eating disorders (18.1% vs. 1.3%), marital maladjustment (27.5% vs. 5.3%), poor quality of life (35.3% vs. 3.3%) and migraine (55.4% vs. 10.7%) was significantly high in PCOS women as compared to controls (p<0.001). Infertility was significantly linked to psychotic implications and PCOS female (p<0.001). So, infertile PCOS patients were more depressed and anxious as compared to fertile. Infertility, especially primary infertility repres...
Rusul Adnan Dawood, Hasan F.K. Alghetaa*
...ome of the physiological disorders taken place in the renal function, immunological response as well as the ability of the redox system represented by total antioxidant capacity and malondialdehyde levels to combat the toxic exposure of mercuric chloride (HgCl2) with or without collaboration of resveratrol (RES) supplement. Forty-five adult Sprague Dawley, 8-10 weeks old female rats weighing 170-220 g were randomly grouped as following; control group (C) kept ...
Abeedha Tu-Allah Khan and Abdul Rauf Shakoori*
...ber of neurodegenerative disorders. While the current understanding of its molecular mechanisms is continually increasing, the identification and consequently the roles of transcription factors (TFs) in the respective molecular events under neuroinflammatory conditions in distinct brain regions is still lacking. To address the said gap in knowledge, first we have identified the TFs specific to IL-1β a key player in mediating inflammatory process using onl...
Nabila Rasheed1, Shumaila Usman2*, Madeeha Sadiq3, Bushra Wasim3, Kanwal Haneef4, Hafsa Shafqat3, Tabinda Urooj3 and Saman Rashid4
...shows that the metabolic disorders like gestational diabetes mellitus (GDM) are not only responsible for several disease factors in adult life but also have adverse effects on perinatal environment as well as on the cellular properties of WJMSCs. This study was designed to determine the effects of gestational diabetes mellitus (GDM) on proliferation of WJMSCs (GDM-WJMSCs). Mesenchymal stem cells were isolated from Wharton’s jelly tissue of normal(healthy...
Salma Jameel Askar
...eatment of hematological disorders, and act as antioxidant. The aim of this study was to examine the effects of sub-chronic exposure to meloxicam, nonsteroidal anti-inflammatory drug, on hematological alterations and liver functions parameters in albino male rats and to determine the effects of Beetroots ethanolic extract in alleviation these alterations. Eighteen male albino rats were used, and they were divided into three groups of six animals each: G1, whic...
Khadija Begum, Azizunnessa and Md Ahaduzzaman*
...f different reproductive disorders. Results show that 12.41% (382/3079) reproductive disorders in does were recorded during the study period. The major reproductive disorders were anestrous (72.25%, 276/382), followed by retained placenta (6.8%, 26/382), and repeat breeding syndrome (4.19%, 16/382). Significant variation in prevalence estimates was observed considering the season (P=0.02) ...
Zhipeng Song1,2, Jialiang Xin1,3, Xiaoli Wei1,2, Abula Zulipiya1,3, Kadier Kedireya1,2 and Xinmin Mao1,3*
...ose and lipid metabolism disorders in db/db mice after a treatment period, so it has positive significance for the prevention and treatment of diabetes. Marein can act on SYK, VEGF and PI3K/AKT factors and change the expression of fibrosis and inflammatory factors in tissues by affecting their pathways. It can integrate with these and many other proteins, and the formed conjugates have a better therapeutic effect....
Mustafa M. Khalaf*, Rana A. Salih
... diseases and autoimmune disorders are treated with cyclophosphamide (CPA). However, as a result of its serious negative consequences, including liver damage associated with oxidative stress, its therapeutic usage is restricted. The most potent antioxidant among flavonoid chemicals is quercetin, the aim of this study was to evaluate the protective effect of quercetin against cyclophosphamide. An explanation of quercetin’s hepatoprotective effects against...
Sajida Batool1, Mubeen Akhtar1, Shafaat Yar Khan1,2*
...ong the common endocrine disorders in childbearing aged females. This study is designed to compare a few anthropometric, hematological, and biochemical parameters in PCOS patients with that of normal females including correlation between interleukin-3 and blood cell count. Patients with PCOS and normal healthy females (n=60) of same age group were included in this study following Rotterdam ESHRE/ASRM criteria. The parameters evaluated were; white and red blood...
Hemeida, A. A., Osman, M., El-Shahat, Mohamed, Hashem, Medhat H., Mahmoud, Amal and Dahi, Hosni
...ts count . Hematological disorders and ALT elevation were common side effects of treatment. The side effects were increased within group B than that of group A. Three random hepatitis C virus (HCV) samples from group B were studied for the diversity and sequence variations. Sequencing of 223 nucleotide of 5'-untranslated region (5'-UTR) was performed. In the phylogenetic analysis, the three sequences and 80 sequences of HCV different genotypes from GenBank wer...
Abou zead, A.A., Ali, A.A.H.*and Abd El Hkeem M.M.
...ng mainly from digestive disorders. Mortality rate, as well as the characteristic clinical signs, , post mortem lesions and histopathological changes were recorded. Serosurvey of 80 serum samples revealed 5 (6.25%) positive for the presence of IBDV precipitating antibodies. 3 out 12 pooled bursae (25%) were positive to the presence of IBDV precipitinogen. Trials for virus isolation on the CAM of chicken embryos revealed the isolation of 3 IBD viruses from...
Tarek Refaay, E.A. Elshafiee, Hayam A. Mansour and Maha A. Sabry*
...ause of gastrointestinal disorders associated with consumption of foods with animal origin. Therefore, this study was conducted to determine the presence of E. coli O157:H7 in food outlets in some touristic cities in Egypt. For this purpose, 648 samples including raw chicken meat, cooked chicken meat, raw beef meat, cooked beef meat, food handlers and equipment swabs were collected from 54 food outlets in some touristic cities in Egypt. E. coli O157 was 1.1% (...
Abdeljabbar Nassiri1, Mouloud Lamtai1*, Inssaf Berkiks1,2, Hajar Benmhammed1, Sidi Mohamed Coulibaly1,3, Miloud Chakit1, Laila Ibouzine-dine1, Abdelhalem Mesfioui1, Aboubaker El-Hessni1
...with numerous behavioral disorders in later life. In young adulthood, a single 24-hour period of MD has been proven to produce behavioral changes such as affective and cognitive disorders in rats. However, the short-term and long-term behavioral consequences of MD have not been examined in detail. Also, the mechanism by which MD causes these disorders is far from fully understood. Therefor...
Mahmoud Hamouda1*, Ahmed Al-Jazzar1, Fahad Al-Hizab1, Ahmed Azab2, Mohamed Al-Hammadi3
...ish that certain uterine disorders may play a significant role in female buffalo infertility. A total of 340 reproductive tracts of female buffaloes have a previous history of infertility was collected from different farms in Egypt through the period of two years. Uteri have been visually and manually inspected as well as examined bacteriologically and histologically. Several uterine lesions either external or internal were noted in 78/340 animals (22.94%) as ...
Wasan Ali Hasan1*, Manal Abdulkhaliq Ibrahim2
...Respiratory inflammatory disorders, including asthma and chronic obstructive pulmonary disease, are prevalent conditions affecting the airways. Current study aimed to investigate the impact of famotidine on respiratory inflammation in rats. Thirty adult male albino rats were segmented into five distinct groups, each group comprising six rats (n=6). A_group (Negative Control) rats received distilled water only, without any drug; B_group (Positive Control) rats ...
Jin Jiao1, Jin Song1, Yuanyuan Cui1, Yilin Wang2, Yanling Li1, Jing Li1, Yan Su1, Xiaojing Du3, Yan Wang3, Guiping Sun3 and Minxiang Wei4*
...etween fatigue and sleep disorders, anxiety and depression, assess the depression status and explore the relationship between myocardial infarction. In this study, 55.3% of patients had sleep disorders, 25.3% had anxiety tendencies with a gender difference, 20.0% had depression tendencies, and 33.2% had fatigue with no gender difference. Anxiety, depression and sleep disturbance were all related to fatigue (P<0.05). The r...
Hayder S. Rwayyih*, Tahani S.S. Al-Azawi
Abdelghafour El-Hamzaoui*, Mouloud Lamtai, Laila Ibouzine‑Dine, Sofia Azirar, Mohamed Yassine El-Brouzi, Ayoub Rezqaoui, Aboubaker El-Hessni, Abdelhalem Mesfioui
...ent of neurodegenerative disorders. These compounds are also suspected of being involved in the induction of affective disorders. The present study was undertaken to examine the dose-dependent impact of GBH exposure over 8-week period on anxiety- and depression-like behaviors in male Wistar rats, administering daily subcutaneous injections of four different doses 25, 50, 75, and 100 mg/kg of GBH while a control group receive...
Thuong Thi Nguyen1*, Nhu Quynh Ho1, Thuan Khanh Nguyen2, Tuan Phong Vu Anh Vo3, Hai Thanh Duong4
...yield to identify health disorders and support early diagnosis of mastitis, ketosis, and abomasal displacement in the dairy cow farm.
Keywords | Alerts, Dairy cows, Milk yield, Rumination, SCR systems
...
Yanfei Cai1, Jiahong Feng1 and Wanlong Zhu1,2,3*
...langeri had no metabolic disorders such as insulin resistance, hypertension, or hyperlipidemia after obesity, and there were also no typical obesity complications such as diabetes, inflammation, or fatty liver. To sum up, we suggest that T. belangeri can be used as an animal model of metabolic healthy obesity, and the special model organism of metabolic healthy obesity will provide us with new opportunities to study obesity problems....
Syed Awais Hussain Shah1*and Rizwan Ali2 2
... malaria, fever, stomach disorders, mouth and throat sour etc. This research provides a lot of Ethnomedicinal knowledge which depicts men’s interaction with plants....
Farrukh Avais1, Anser Ali1, Hamza Javed2, Muhammad Saleem3, Tehreem Tahir4,
Muhammad Rafiq5,*
...on leads to various skin disorders like melasma, sunspots, age
spots and freckles. Moreover, abnormal skin pigmentation is a serious aesthetic concern
which leads to psychosocial problems. Thus to achieve melanin inhibition, inhibition of
tyrosinase might be an effective approach. To this end we prepared methanolic (MeOH)
extracts from leaves and roots of Garlic Allium sativum (AS) and Peppermint Mentha
Eman Ali Hussein1*, Majdy Faisal Majeed2
...mmon metabolic endocrine disorders is diabetes mellitus. Nephropathy may be one of the causes of continuous uncontrolled non-insulin-dependent diabetic mellitus (NIDDM). It has been shown that streptozotocin (SZ)-induced oxidative stress damages pancreatic beta cells and results in hyperglycemia in rats, which leads to diabetic nephropathy. The goal of this investigation was to see if Trigonella foenum-graecum (TFG) flavonoid extract could protect the kidneys ...
Samin Jan, Mir Ajab Khan, Siraj ud din, Waheed Murad, Manzoor Hussain , Aneela Ghani
Sumaira Fiaz1*, Huma Naz1*, Tanveer Ahmed2*, Iqra Zulfiqar1, Khalid Mehmood1, Muhammad Jabbar1, Syed Qaswar Ali Shah1, Muhammad Usman4
... Some other histological disorders were also seen in liver of Cd-treated fish viz. infiltration of sinusoid, dilation and increased hemorrhage in sinusoids, inflammation and vacuolation in hepatocytes and ruptured hepatocytes after 60-days of experimental period. Hepatosomatic index was significantly less in Cd-treated fish than control fish throughout the experimental period. Addressing this problem requires a coordinated effort among governments, industries,...
Sarfaraz Hussain Bangash
...utrients. Many plant disorders have been recognized as trace element deficiencies. Recommendations have, therefore, been made to use minimal supplements of trace elements for all chemical fertilizers to minimize the fluctuations and availability of these elements to plants. Amongst the micro-nutrient elements, boron is perhaps the most important and plays a very important role in soil-plant relationship. It has a marked effect on crop growth, both from the...
Fatima Aziz Mahdi Al-Badry
...lammation and structural disorders such as breakdown, death and absence of glomeruli with increasing of Bowman’s space. while these histological changes in liver were included congestion, hemorrhage, hypertrophy as well as necrosis of the hepatocytes. Conclusion: It was concluded in this study eating of Puma for long times causes renal-hepatic damages.
Keywords | Puma, (Super fat), Histopa...
Hina Ilyas1, Umar Hanif2, Anser Ali1, Zahid Hassan Tarar3,Hamza Javed4, Tehreem Tahir5, Muhammad Rafiq6*
...igmentation causing skin disorders like freckles, melasma and black spots. Therefore, search for new tyrosinase inhibitors is desirable. In present study, methanolic (MeOH) extracts from leaves, fruit peel and pulp of Citrus bergamia (C. bergamia) and, leaves and fruit of Ficus carica (F. carica) were prepared which were further processed for fractional distillation using ethyl acetate (EA), n-hexane (n-Hx) and chloroform (CHCl3) preparing total 20 extracts ai...
Aura Oktiefa Adyantono, Sugiharto Sugiharto, Daud Samsudewa*
... to several reproductive disorders, and poorer reproductive qualities. The research about the reproductive quality between two species showed different result. The aim of this research is to compared the reproductive quality of Bos indicus crossbred and their crossbreds with Bos taurus. A meta-analysis involving 43 studies on reproductive hormone levels, 25 studies on estrus activity and 65 studies on reproductive performance. Article search, article selection...
Tahani Ahmad Al-Matrafi1, Zuhair M. Mohammedsaleh2, Mamdoh S. Moawadh2, Waheeb S. Aggad3, Rawabi Mohamed almuhimed4, Zamzam Alhuwaymil5, Aishah E Albalawi6, Ifat Alsharif7, Hailah M. Almohaimeed8, Fatima S. Alaryani9 and Mona H. Soliman10,11*
...oica in mitigating liver disorders, emphasizing its promising role as a natural hepatoprotective agent....
Baraa Najim Al-Okaily
...Chronic liver and kidney disorders are highly widespread globally and are intricately linked to oxidative stress, a phenomenon that has been extensively studied and highlighted for many years. Collectively, we can conclude that the oxidative stress is normal when there is a balance between the production rate and scavenger rate. However, it could be detrimental when the ability of body is insufficient to control the production rate or incapable to remove the h...
Laila Ibouzine-Dine1*, Inssaf Berkiks1,2, Hasnaa Mallouk1, Mouloud Lamtai1, Zineb El Marzouki1, Amal Dimaoui1, Abdelhalem Mesfioui1, Aboubaker El Hessni1
...ed with neuropsychiatric disorders, including depression. While the nitric oxide (NO) pathway is implicated in depression, how changes in NO kinetics impact sex-dependent affective behaviors has not been thoroughly investigated. This study focuses on the effects of LPS-induced early immune challenge on NO release kinetics in the neonatal rat brain, as well as the link between these effects and long-term sex- and age-related behavioral changes in adolescence. T...
Idrissi Ouedrhiri Housna1, Bikri Samir1,2*, Benloughmari Douae1, Aboussaleh Youssef1
...tributing to psychiatric disorders. Melatonin (MEL), known for its potent antioxidant properties and various benefits against hyperglycemia and stress-related complications, is particularly intriguing. The primary objective of this study was to investigate whether combining Melatonin and Metformin (MET) could ameliorate biochemical and behavioral changes associated with persistent hyperglycemia, specifically by reducing lipid peroxidation (LPO), a key marker o...
Meray Nabil Ramsis
...o diagnose and treat eye disorders. In order to assist corrective surgeries, this study identified particular variations in the ocular arteries of donkeys in comparison to other species. Ten healthy adult donkey’s cadavers were used. Six of them were injected with heparin into the common carotid artery and they are subsequently washed with a warm saline solution of 0.9%. 60% gum milk latex neoprene, stained with red Rottring ink, was injected in order to...
Rico Anggriawan1*, Widya Paramita Lokapirnasari2, Sri Hidanah3, Muhammad Anam Al Arif4, Diyah Ayu Candra5
...igestive and respiratory disorders. The chicken farming industry, especially broiler chickens, often uses antibiotics to cure bacterial infections and secondary infections caused by bacteria. One of the microorganisms that cause digestive and respiratory diseases in broiler chickens is the bacteria. Treatment of bacterial infections with antibiotics is increasing every year. Broiler chickens infected by gram-positive and gram-negative bacteria are often treate...
Manel Ben Larbi1*, Ameni Askri1, Mariem Saidani1, Naceur M’Hamdi2, Ibrahim El Akram Znaïdi3, Nadia Ben Braiek4 and Hajer M’Hamdi5
...fare such as painful leg disorders and heart failure in broiler chickens and hunger due to severe food restriction in the breeding birds. The scientific literature on broiler chicken welfare in Tunisia is scarce. This study aimed to assess broiler welfare conditions in five Arbor Acres commercial flocks at the age of 35 days. Some indicators were observed like hock lesions, lameness, pododermatitis, plumage cleanliness, and breast blister. The scores of welfar...
Farida Bibi2, Zahin Anjum1*, Imran Khan3, Shaista Ali1 and Rabia Chishti1
...ng the major nutritional disorders that are related with the diet of community. The research study was a challenging one as it was an exploratory study it gave an insight both to the cultural relevance of commonly consumed breakfast in Peshawar and its macro-nutrient content....
Ozdan Akram Ghareeb1*, Goljameen Midhat Abdulla1, Sanaz Sheikhzadeh2
...ated with immune-related disorders at high doses. This study aimed to evaluate the As-induced acute hepatotoxicity and the role of immune response through inflammatory cytokines in laboratory rats. Eighteen adult male rats were employed in present study, and they were set into three groups (n = 6/group). First group acted as control (CON) without any treatment, while other two groups were exposed to sodium arsenite orally at a single dose (13 mg/kg) Animals we...
Afshan Kaleem*, Iqra Noor, Roheena Abdullah and Mehwish Iqtedar
...eutic leads for specific disorders (colon cancer and memory improvement in Alzheimer’s disease). Phytochemical testing showed the presence of various bioactive compounds including flavonoids, steroids, carbohydrates, proteins, glycosides, saponins, phenols etc. Antibacterial analysis of aqueous extracts of Phaseolus vulgaris and Vigna unguiculata were done by using the disc diffusion method, which showed that both extracts have potential antibacterial ac...
Khoula Begum* and Imran Khan
...lar health and metabolic disorders, ultimately contributing to the development of dietary strategies for the prevention and management of cardio-metabolic diseases....
Sofia Azirar*, Abdelghafour El Hamzaoui*, Mouloud Lamtai, Mohamed Yassine El Brouzi, Aboubaker El Hessni, Abdelhalem Mesfioui
... Hippocampus, Behavioral disorders
... 
