Allele Frequency Distribution of CYP2C19*3 and CYP1A1 Allelic Variants Associated with Clopidogrel Resistance in Cardiac Patients of Pakistan
Allele Frequency Distribution of CYP2C19*3 and CYP1A1 Allelic Variants Associated with Clopidogrel Resistance in Cardiac Patients of Pakistan
Kashif-ur-Rehman1,2, Ahmad Bakhsh1, Muhammad Akram Tariq3,
Muhammad Khalil Ahmad Khan4 and Sumaira Mehboob1*
Amplification strategy for allele specific extension of CYP2C19*3 (rs4244285) as an example.
Gel image showing amplified products for allelic variant A and G wild type of CYP2C19*3.
Sanger sequence chromatogram for wild type CYP2C19*3G showing complementary SNP C at position 102 (reverse strand sequenced).
Sanger sequence chromatogram for allelic variant CYP2C19*3A showing mutated SNP T at position 102 (reverse strand sequenced).
Gel image showing amplified products for wild type A and allelic variants C, G of CYP1A1.
Sanger sequence chromatogram for wild type A of CYP1A1 showing complementary SNP T at position 168 shown by arrow (Reverse strand sequenced).
Sanger sequence chromatogram for mutant type C of CYP1A1 showing complementary SNP G at position 170 shown by arrow (Reverse strand sequenced).
