Analysis of Influencing Factors of Different COVID-19 Vaccinations on COVID-19 Infected Patients in Shanghai
Analysis of Influencing Factors of Different COVID-19 Vaccinations on COVID-19 Infected Patients in Shanghai
Chonglin Yang1, Cuiping Yang2*, Jingwen Jiang3, Haifang Lai4 and Wenqiang Xia5
ABSTRACT
Vaccination with COVID-19 vaccine can reduce the incidence of severe coronavirus infection and death. Different vaccinations have different impacts on patients who suffered COVID-19. However, the correlation between the dose and times of vaccination and the natural course of disease after infection has not been determined. The objective of this study was to analyze the correlation between the type, dose, times of vaccination and the time of negative turning, clinical symptoms and the natural course of disease. Retrospective analysis was adopted for which the patients who tested positive for COVID-19 nucleic acid in the study according to the consensus opinion of China’s COVID-19 infection were included. A total of 210 asymptomatic and mild COVID-19 patients, 116 males and 94 females, with an average age of 46 years, BMI of 24.43±5.62, were enrolled in this study from March 21 to April 8, 2022 in Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Novel coronavirus asymptomatic infections were 126 cases, and mild patients were 84 cases. The patients were grouped according to the dose of COVID-19 vaccine before infection. The gender, age, BMI, symptoms, complications, vaccine manufacturer, the interval between the last vaccination and COVID-19 infection, and the duration of disease were analyzed. We found that the average age of patients in the unvaccinated group was significantly higher than that in the other groups, and the duration of the disease was slightly longer than that in the vaccinated group (P < 0.05). The differences between groups were statistically significant, but there was no significant difference between groups with different doses. There was no significant difference in BMI among the groups. According to the types of underlying diseases, the disease duration of the non-complications group was shorter than that of the complications group (P > 0.05), but there was no significant difference between the complications group. There was no significant difference in the duration of disease between the groups according to vaccine manufacturer. According to the interval from the last vaccination to infection, the duration of disease in the unvaccinated group was significantly longer than that in the other groups, and there was no significant difference between the duration of disease in patients with an interval of more than 1 year and the unvaccinated group. To conclude asymptomatic and mild symptoms are more common in young and middle-aged patients with normal weight or overweight. The number of days of nucleic acid turning negative in patients with underlying diseases was significantly longer than that in patients without underlying diseases, but it was not related to several underlying diseases. No matter how many doses of vaccine have been administered, and no matter what type of vaccine has been administered, the natural course of disease can be significantly shortened compared with the unvaccinated. The infection rate of novel coronavirus is lower within 3 months after vaccination. When the interval after the last vaccination was more than one year, the natural course of disease was prolonged, which was not significantly different from that of unvaccinated subjects.
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