Assessing the Pathological Diagnostic Skills of Veterinary Students for Ovine Pulmonary Adenocarcinoma
Assessing the Pathological Diagnostic Skills of Veterinary Students for Ovine Pulmonary Adenocarcinoma
Ibrahim Elmaghraby1, Osama Ahmed2,3, Shymaa Moustafa4 and Salma Shoulah4*
ABSTRACT
Ovine pulmonary adenocarcinoma (OPA) is a contagious neoplastic disease of sheep caused by Jaagsiekte sheep retrovirus (JSRV). This study assessed the morphological and histopathological characteristics of OPA in sheep and levels of awareness and understanding of OPA in veterinary students. A survey among clinical-grade students revealed higher recognition of JSRV as the primary cause. Postmortem examination of affected sheep showed enlarged lungs with gray nodules and frothy fluid exuding from lung nodules. Histopathological analysis showed the proliferation of neoplastic cells in the alveolar and bronchial linings, displaying papillary, solid, or acinar patterns. These neoplastic cells replaced normal epithelial cells, while the surrounding stroma exhibited infiltration by mononuclear inflammatory cells. Additionally, secondary changes were observed in the kidneys, liver, and lymph nodes, including mild interstitial fibrosis, vacuolar degeneration, and lymphoid depletion, respectively. The study emphasizes the critical need for early diagnosis and the development of effective diagnostic methods to identify infected sheep and curb the spread of JSRV infection. These findings enhance students’ practical skills in managing real-life cases and reinforce the value of histopathological examination in veterinary diagnostics.
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