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Bio-screening of Chalcone and Aurone analogues as therapeutic agents

Bio-screening of Chalcone and Aurone analogues as therapeutic agents

MUHAMMAD MANSHA*1, QAMAR ALI1, UROOJ FATIMA DILAWARI1, ABRAR HUSSAIN1 & MUHAMMAD TARIQ1

1Department of Zoology, Township Campus, University of Education, Lahore, Pakistan

 
*Corresponding Author:
Muhammad Mansha:
dr.mansha@ue.edu.pk

ABSTRACT

Chalcones and aurones are compounds having appealing pharmacological profile due to presence of carbonyl system. The bio-screening of 13 compounds was conducted and assessed against S. aureus, C. albicans and E. coli by agar well diffusion method. Chalcones analogues 1, 2, 3, 4, 5, 6, 7, and 8 were found to be inactive or insignificant against E. coli. Chalcone analogue 9 showed moderate activity against E. coli. Similarly, compounds, 1, 2, 3, 6, 7, 8 and 9 were found to be inactive or insignificant against S. aureus. Analogues 4 and 5 displayed moderate bioactivity against S. aureus. Similarly analogues 1, 2, 4, 7, 8 and 9 were found to be inactive or insignificant against C. albicans. Compound 3, 5, and 6 were found more effective against C. albicans. Among aurones 2, 3, and 4 showed insignificant activity while compound 1 showed significant activity against E. coli. Analogue 1 showed very effective acitivity against S. aureus. In a similar way, analogue 3 was found to be inactive, while analogues 1, 2 and 4 showed moderate activity against C. albicans. Overall, chalcone and aurone analogues have been effective against selected bacteria and fungi strains and are expected to be effective in other bioscreening studies.

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Biologia (Lahore)

December

Vol.65, Iss. 2

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