Bioinformatics Analysis of Promoter Methylation and Clinical Significance of Tumor Suppressor Gene HOXA5 in Oral Cancer

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Bioinformatics Analysis of Promoter Methylation and Clinical Significance of Tumor Suppressor Gene HOXA5 in Oral Cancer

Haichao Wang^1,2, Yi Liu^1,2, Jingwen Wu^1,2, Wenjing Wang^1,2, Hongyi Zhang^1,2* and Cunjian Yi³*

Author Affiliations

¹Department of Stomatology, The First Affiliated Hospital of Yangtze University, Jingzhou, 434000, Hubei Province, China

²Department of Stomatology, The First People’s Hospital of Jingzhou, Jingzhou, 434000, Hubei Province, China

³Department of Gynecology, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China

* Corresponding author: [email protected], [email protected]

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Fig. 1.

Analysis of HOXA5 mRNA expression levels in OC cells. A, CAL-27; B, H357; C, HSC-3

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Fig. 2.

Real-time time RT-PCR detection of GAPDH gene in OC cells. A, CAL-27; B, H357; C, HSC-3.

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Fig. 3.

Induction of HOXA5 mRNA expression in OC cells by different concentrations of 5Aza-CdR.

A, concentration = 0.01; B, concentration = 0.05; C, concentration = 0.1; D, concentration = 0.5; E, concentration = 1; F, concentration = 5.

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Fig. 4.

Comparative analysis of methylation in patients with OC and oral ulcer.

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November 2024

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Bioinformatics Analysis of Promoter Methylation and Clinical Significance of Tumor Suppressor Gene HOXA5 in Oral Cancer

Haichao Wang^1,2, Yi Liu^1,2, Jingwen Wu^1,2, Wenjing Wang^1,2, Hongyi Zhang^1,2* and Cunjian Yi³*

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Haichao Wang^1,2, Yi Liu^1,2, Jingwen Wu^1,2, Wenjing Wang^1,2, Hongyi Zhang^1,2* and Cunjian Yi³*