Changes in Intestinal Flora Diversity and Intestinal Immune Barrier in Patients with Ulcerative Colitis
Changes in Intestinal Flora Diversity and Intestinal Immune Barrier in Patients with Ulcerative Colitis
Xiaodong Lin*, Guangyao Wu and Fu Zhang
ABSTRACT
The objective of this study was to analyze the changes of intestinal flora diversity and intestinal immune barrier in patients with ulcerative colitis (UC). The present study included 58 UC patients admitted to the Department of Gastroenterology in Dongguan Kanghua hospital from August 2017 to August 2019 and enrolled into the observation group. According to Mayo scores, 58 UC patients were divided into remission stage(n=25) and active stage (n=33). Another 50 healthy people who did not have intestinal lesions at the same time were selected as controls. The immunohistochemically results demonstrated that occludin positive cells were mainly expressed in the cell membrane and cytoplasm of epithelial cells and glandular cells, with brownish yellow staining particles. The expression of occludin positive cells in the observation group was significantly lower than that in the control group (P<0.05). β - defensin positive cells were mainly expressed in the cytoplasm of intestinal epithelial cells and interstitial cells, with a small amount in the nucleus. The expression of SIgA was significantly higher in the observation group than in the control group (P<0.05). SIgA positive cells were primarily expressed in epithelial cells and plasma cells in the lamina propria, and its expression level in the observation group was significantly lower than that in the control group (P<0.05). It was concluded that the UC destroys the intestinal mechanical barrier and immune barrier resulting in the dysfunction of intestinal mucosa barrier.
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