Comparison of Two Inactivated Vaccines Against Infectious Bronchitis Virus Evidences the Interference of Vaccine Formulations on Vaccine Performance
Lucas Pedroso Colvero1, Paulo Eduardo Brandão2*, Cesar Alejandro Rodriguez Rosales2, Hanny Swam3 and Laura Yaneth Buitrago Villarreal1
1MSD Animal Health Brazil. Avenida Dr. Chucri Zaidan, 246-96, CEP: 04583-110. São Paulo, SP, Brazil; 2Department of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, Av. Prof. Dr. Orlando, Marques de Paiva, 87, CEP 05508 270, São Paulo, SP, Brazil; 3MSD Animal Health The Netherlands. Wim de Körverstraat 35, 5831 AN Boxmeer, The Netherlands.
[email protected]
Figure 1
Light microscopic view (400x) of vaccine A and B evidencing differences in droplet sizes and in emulsion homogeneity.
Figure 2
Mean ELISA S/P ratios for anti-IBV antibodies (vertical axis) for SPF chickens vaccinated with vaccine A (triangles), B (squares) and control birds (circles) at weeks 2, 4 and 6 pots-vaccination (horizontal axis). Numbers close to each point are mean S/P values; values at week 0 (prior to vaccination) were 0.005, -0.003 and -0.001 for vaccines A, B and C, respectively, and are not shown on the graph due to their proximity.