Cytochrome-P450 (CYP11B1 Gene) Polymorphism and its Role in Bovine Milk Producing Traits
Cytochrome-P450 (CYP11B1 Gene) Polymorphism and its Role in Bovine Milk Producing Traits
Faheen Riaz1, Sarfraz Mehmmod1, Aatka Jamil1, Khansa Jamil1, Imran Riaz Malik2, Muhammad Naeem Riaz1* and Ghulam Muhammad Ali1
ABSTRACT
A newly developed strategy with enormous promise is genomic selection for features that are important to the economy. Numerous polygenic characteristics, including milk output, protein content, and fat, have been characterized at the genome level, and significant selection signatures have been found. The ability to uncover causative genes and variants linked to many phenotypes has been made possible in recent years by advancements in high-throughput genome scanning techniques, most notably whole-genome sequencing, SNP genotyping arrays, and comparative genomic hybridization (CGH) arrays. The next-generation sequencing method is an effective way of locating functional genes and genetic variations linked to crucial economic features in livestock when compared to the other two methods. The most significant economic qualities in the dairy industry are milk yield and composition, which are typical quantitative traits that are simultaneously regulated by many QTLs and polygenes. The cytochrome P450 enzymes can impact several dairy functions. Steroid 11-beta-hydroxylase is a mitochondrial enzyme that is produced using instructions from the CYP11B1 gene. In cattle, it facilitates the conversion of 11-deoxy-cortisol to cortisol and 11-deoxycorticosterone to corticosterone. The protein produced by the bovine CYP11B1 gene, which has nine exons and eight introns and is located on BTA14q12, is linked to the mitochondrial epithelium. The CYP11B1 gene is located close to the marker ILSTS039, this marker is connected to milk characteristics. This makes the CYP11B1 gene, along with milk yield and milk component yield, the functional and positional candidate gene for the milk production traits.
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