Distribution of Pathogenic Bacteria of Postoperative Wound Infection and Early Prediction Value of Serum in Children with Hypospadias
Distribution of Pathogenic Bacteria of Postoperative Wound Infection and Early Prediction Value of Serum in Children with Hypospadias
Mimi Jin*, Xiaoye Hu, Lijing Yu, Shuangli Zheng, Huishuang Huang and Fang Chen
ABSTRACT
The objective of this study was to investigate the distribution of pathogens and the early predictive value of serum in children with hypospadias. The sample consisted children with hypospadias between January 2019 and December 2021 at the Second Affiliated Hospital. 136 children were treated with operation and one-stage urethral reconstruction and divided into infection group (n=18) and non-infection group (n=118). The multivariate logistic regression analysis showed that Snodgrass, penile downward curve, scrotal dysplasia, prolonged operation time, C-reactive protein (CRP), soluble myeloid triggered receptor 1 (sTREM-1), soluble intercellular adhesion molecule-1 (sICAM-1), white blood cell (WBC) and neutrophil / lymphocyte ratio (NLR) at 24 h after operation were the risk factors for postoperative wound infection in children with hypospadias (P<0.05). ROC curve analysis showed that the ROC-AUC predicted by CRP, sTREM-1, sICAM-1, WBC and NLR at 24 h after operation were 0.729, 0.788, 0.821, 0.833, 0.765 and 0.802 respectively. The ROC-AUC of the combination of the above infection indexes was 0.904. The main wound infection after hypospadias is gram-negative bacteria infection. Snodgrass, penile curvature, scrotal dysplasia, prolonged operation time and more than 24 h after operation can increase the risk of wound infection in children with hypospadias. The combination of the above infection indexes has important value in predicting wound infection, and more attention should be paid to the children with the above risk factors in clinical nursing.
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