Relationship between Serum sEng, PLGF, Gal-1 Levels and Pregnancy Outcome in Pregnant Hypertensive Mothers during Pregnancy
Relationship between Serum sEng, PLGF, Gal-1 Levels and Pregnancy Outcome in Pregnant Hypertensive Mothers during Pregnancy
Yanfang Wu, Lei Chen* and Xiaoning Jia
ABSTRACT
The objective of this study was to observe the relationship between serum levels of soluble fms-like tyrosine kinase-1 (sEng), placental growth factors (PLGF), and galectin-1 (Gal-1) in hypertensive pregnant women during pregnancy and the pregnancy outcome. The study used convenience sampling method to select 375 pregnant women with hypertension in pregnancy attending the clinic from March 2020 to April 2023, and general information questionnaire, enzyme-linked immunosorbent assay was used to determine the serum sEng, PLGF, Gal-1 levels of the pregnant women at the time of admission to the hospital. The pregnant women were followed up for 6 months and 319 cases were completed, and the pregnancy outcome was defined by the presence of preterm labour, intrauterine foetal growth retardation, and placenta previa. Pearson correlation, logistic regression, and ROC curve analyses were used to determine the correlation and diagnostic efficacy of each index with pregnancy outcome. Serum sEng, PLGF, and Gal-1 levels were positively correlated with preterm labour, intrauterine fetal growth retardation, and placental abruption. Binary logistic regression analysis determined that serum sEng, PLGF, and Gal-1 levels were independent risk factors for preterm labour and intrauterine fetal developmental delay; initial diastolic blood pressure at admission and serum Gal-1 levels were independent risk factors for placental abruption; and serum sEng, PLGF, and Gal-1 were good diagnostic factors for preterm labour and intrauterine fetal serum sEng, PLGF, and Gal-1 had good diagnostic efficacy for preterm labour and IUGR. It was concluded that there is a close relationship between serum levels of sEng, PLGF, and Gal-1 in hypertensive pregnant women and their pregnancy outcome. These three substances can be used as biomarkers of maternal preterm labour and foetal growth retardation, and their elevated levels can help to assess the pregnancy outcome of hypertensive pregnant women during pregnancy.
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