Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease
Effect of Clopidogrel Combined with Atorvastatin on Serum Lipids, Inflammatory Factors and Cardiac Function Parameters in Patients with Angina Pectoris and Coronary Heart Disease
Jiaojiao Ma*, Jialei Jiang and Lijun Shan
ABSTRACT
The objective of this study was to analyze the regulatory effect of Clopidogrel combined with Atorvastatin on the low-density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), and total cholesterol (TC) in patients with angina pectoris and coronary heart disease. Eighty-three patients admitted to a hospital from January 2021 to December 2022 are research subjects. The enrolled patients are randomly numbered 1-83. Patients with odd numbers (42 cases) and even numbers (41 cases) are included in the control group (CG) and the observation group (OG), respectively. On the basis of routine treatment, the CG patients are treated with low molecular weight heparin and aspirin. The OG are treated with Clopidogrel and Atorvastatin. The changes in serum lipids, inflammatory indicators, and cardiac function are compared between the two groups before the treatment (Time 0), after 2 weeks of the treatment (Time 1), and after 4 weeks of the treatment (Time 2). There is no significant distinction in serum lipid, inflammatory indicators, and cardiac function between groups at Time 0 (P>0.05). While the serum lipids and inflammatory indicators levels at Time 1 and Time 2 are below those at Time 0and the levels at Time 2 are lower than those at Time 1, the cardiac function levels at Time 1 and Time 2 are higher than those at Time 0, and the levels at Time 2 exceed those at Time 1. So, the serum lipids and inflammatory indicators levels in the OG are below those in the CG (P<0.05), but the cardiac function levels are higher. The results showed that the levels among groups, time, and interaction is significant (P<0.05). Clopidogrel combined with Atorvastatin can effectively reduce the serum lipid levels and inflammatory factors in patients, which is conducive to improving the cardiac function of patients.
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