Effect of Ginseng on Blood Lipid Profile, Testosterone Level and Epididymal Sperm Quality of Aged BALB/C Mice
Effect of Ginseng on Blood Lipid Profile, Testosterone Level and Epididymal Sperm Quality of Aged BALB/C Mice
Muhammad Tayyab Khan1*, Muhammad Irfan-ur-Rehman Khan1, Tehmina Yasmin2, Ghulam Shabbir Khan1 and Amjad Riaz1*
ABSTRACT
It is well known that aging in males leads to male infertility; therefore, the current study determines the impact of ginseng on blood lipid profile, testosterone level, and epididymal sperm quality in aged balb/c mice. Aged male mice (n=48) were assigned to three groups (n=16 in each) i.e., control (CON), high dose ginseng (HDG) and low dose ginseng (LDG). Mice were treated as CON (normal saline), HDG (500 mg/kg/day) and LDG (250 mg/kg/day) for 5 weeks. Daily feed intake, weekly weight, blood lipid profile, testosterone level, epididymal sperm quality, and testicular tissue were evaluated during and 5 weeks after the end of treatment. Results revealed that weight gain and feed intake decreased (P< 0.05) in mice treated with HDG and LDG than CON during and 5 weeks after the treatment. During the treatment, levels of testosterone, cholesterol, and low-density lipoproteins increased (P< 0.05) in mice treated with HDG and LDG than CON; however, cholesterol, triglyceride, and LDL-C were increased in CON than HDG and LDG treated mice after 5 weeks of treatment. Motility and viability (%) of spermatozoa increased (P< 0.05) in HDG and LDG treated mice than those of CON mice whereas sperm concentration was more (P< 0.05) in LDG than HDG and CON treated mice during the treatment. Five weeks after the treatment, motility and viability of spermatozoa were greater (P< 0.05) in HDG and LDG than CON treated mice. In conclusion, Ginseng treatment in aged BALB/c mice enhances the epididymal sperm quality, lipid profile and blood testosterone level during and even five weeks after the end of treatment period.
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