Genotoxicity and Anti-Cancer Activity of Tamoxifen and Ivermectin Loaded Chitosan Nanoparticles Against MCF-7 Cell Line
Genotoxicity and Anti-Cancer Activity of Tamoxifen and Ivermectin Loaded Chitosan Nanoparticles Against MCF-7 Cell Line
Usama Bin Naeem1, Muhammad Adil Rasheed1*, Muhammad Ashraf1 and Muhammad Yasir Zahoor2
Fig. 1.
Fourier transform infrared (FTIR) spectroscopy. (A) Chitosan; (B) TAM-CsNPs; (C) IVM-CsNPs.
Fig. 2.
Zeta sizer and zeta potential of TAM-CsNPs and IVM-CsNPs. (A) TAM-CsNPs; (B) TAM-CsNPs; (C) IVM-CsNPs; (D) IVM-CsNPs.
Fig. 3.
Scanning electron microscope (SEM). (A) TAM-CsNPs; (B) IVM-CsNPs.
Fig. 4.
Drug entrapment efficiency of (A) TAM-CsNPs (B) IVM-CsNPs at pH 7.4.
Fig. 5.
In vitro drug release of TAM-CsNPs (A) and IVM-CsNPs (B) at 6.0 and 7.4 pH for 24 h.
Fig. 6.
Comets taken from a fluorescent microscope representing DNA damage since the head size is greater than length of tail (Comet formation).
Equation 1
Equation 2
Equation 3
