The Value of Procalcitonin Combined with C-Reactive Protein Assay in the Early Clinical Diagnosis of Bloodstream Infection
The Value of Procalcitonin Combined with C-Reactive Protein Assay in the Early Clinical Diagnosis of Bloodstream Infection
Cheng-Hong Chen and Ling-Xian Ding*
ABSTRACT
This study aims to investigate the application value of procalcitonin (PCT) paired with C-reactive protein (CRP) in the early diagnosis of bloodstream infection. This study involved 298 patients with suspected bloodstream infections who were hospitalized in our hospital between March 2016 and March 2018. All patients were examined by blood culture, and the PCT and CRP levels were examined to observe the diagnostic value of PCT and CRP. Of the 108 patients with positive blood culture and 190 patients were negative. Serum PCT (12.25±1.36) pg/mL and CRP (84.26±2.81) mg/mL were higher in the positive group than in the negative group (1.26±0.25) pg/mL, (39.12±1.69) mg/mL, the difference was statistically significant (t=16.513, 19.581, P<0.05); PCT+CRP sensitivity was 97.22%, specificity was 90.53%, positive predictive value was 85.37%, and negative predictive value was 98.29%. To conclude the application of PCT combination with CRP detection in the early clinical diagnosis of bloodstream infection has better application value, better sensitivity and strong specificity, which can be widely used in clinical practice.
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