Analgesic Effect of Nalbuphine Combined with Sufentanil After Laparoscopic Hysterectomy
Analgesic Effect of Nalbuphine Combined with Sufentanil After Laparoscopic Hysterectomy
Zhenfeng Cai1, Xingli Jiang2, Xintao Dai1 and Pinglei Wu1*
ABSTRACT
The objective of this study was to examine the effect of PCIA analgesia after laparoscopic hysterectomy (LH) with Nalbupine combined with Sufentanil on Visual Analogue Scale/Score (VAS), Ramnsay sedation score, serum prostaglandin E2 (PGE2), 5-hydroxytryptamine (5-HT). A convenient sampling method was used to select 86 patients who were scheduled to undergo total LH from March 2020 to April 2022. The patients were divided into control group (CG) and research group (RG), 43 cases each. All patients are treated with PCIA, CG with Sufentanil+Granisetron, RG with Nalbuphine combined with Sufentanil+Granisetron. At 6h and 12h after operation, the scores of VAS and Ramnsay sedation was lower in the RG. The PGE2 and 5-HT water of the RG patients at 6h, 12h and 24h after operation were lower on average. The total adverse reactions incidence in the RG, PCIA press times and tramadol administration times were lower. It was found that Nalbupine combined with Sufentanil can effectively reduce the postoperative pain degree of patients, reduce the release of PGE2 and 5-HT pain factors in serum, and reduce PCIA press number and tramadol administration number.
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