Ayesha Noreen1, Dilara A. Bukhari2 and Abdul Rehman1,*
...ole in cancer growth and metastasis. ROS and tumor cell interaction could activate the signalling pathways, promoting cell proliferation, invasion, inducing angiogenesis, inflammation and cellular transformation in cancer. A better understanding into the mechanism of ROS in cancer progression might be useful for the development of biomarkers and therapeutic strategies. The objective of this review was to summarize the roles of ROS in different stages of cancer...
Muhammad Khan1,*, Amara Maryam2, Hafiz Abdullah Shakir1, Javed Iqbal Qazi1 and Yongming Li3,*
...wn to induce lung cancer metastasis. In the present study, we found for the first time that Baohuoside I (BHS-1), a natural flavonol glycoside inhibits BaP-induced A549 lung cancer metastasis by modulating the expressions of p-STAT3, COX-2, MMP-2, MMP-9, E-cadherin and N-cadherin. Moreover, we found that chronic BaP exposure promoted migration without enhancing the proliferation of cells and BHS-I was equally toxic to both B...
Rıfat Ertekin1*, Mete Ozkurt1, Gokhan Kus2 and Selda Kabadere1
...mergence of cancer or in metastasis, this study shows TA has an antiproliferative and stimulating effects on apoptosis of LNCaP cells based on the dose and duration of exposure.
...
Bo Gao1,2, Fengmei Yang3, Wei Chen2, Xiaojia Song4, Xiaobo Liu5 and Dongmin Li1*
...tiation and/or lymphatic metastasis, as well as variations in negative and positive expression between survival and recurrence times, were statistically significant. The level of tumor markers at 6 months after operation was significantly lower than that before operation in recurrent/non-recurrent and MDR1 positive/MDR1 negative group. There was a significant correlation between MDR1 expression and tumor markers (CA125 and CA153), regardless of whether recurre...
Ho-Seong Cho1 and Yeonsu Oh2,*
Longjun Guo*, Jiaqi Teng, Juan Wang and Yukun Chen
...lay the distribution and metastasis of brain nerve fibers or white matter. In terms of leukoaraiosis degree, FA decreased. Where, DR increased, AMO decreased, Dave and DAx remained unchanged. Most FA reduction observed in white matter was observed in the corpus callosum. In the end we concluded τ protein expression in cerebrospinal fluid can enable identification of the occurrence of LA symptoms to a certain extent. Its combined use with DTI, an important ...
Seun Eui Kim1,2*, Myoung-Hoon Lee1, Hye Myoung Jang2, Garam Park2, Wan-Taek Im3, Gwang Joo Jeon2,4*
...d MMP9 related to cancer metastasis and invasion was significantly increased or decreased in the CK-treated group, showing that CK properly and antagonistically works on anticancer activity. The expression of angiogenesis-related gene of VEGF unexpectedly was increased. In conclusion, this study confirmed that ginsenoside CK is a new anticancer candidate with excellent anticancer activity inducing cell cycle arrest, apoptosis and in some extent cell migration/...
Qi Zhuo, Yuanchun Yao, Meisongzhu Yang*, Jinhua Chen and Miao Tian
...iting the proliferation, metastasis and invasion of breast cancer cells. Tissue samples (28) were collected, and malignant and normal tissues were confirmed pathologically. The breast cancer cell line MDAMB-231 and the immortalized normal breast epithelial cell line MCF-10A were used in this study. Western blot analysis of miR-216b-5p and HDAC8 protein expression in tissue samples; reverse transcription quantitative PCR (RT-qPCR) real-time analysis of miR-216b...
Xiajun Zhang1, Jie Yang2, Wenjun Zhou1, Zhenshi Chen2, Weidong Wu3, Shaoru Zhang2 and Lihui Wang2*
...ration, angiogenesis and metastasis, and is an inducer of epithelial-mesenchymal transformation. Tumor cells activate the TGF-β/Smad pathway, and inhibiting its signal transduction pathway is an important strategy for tumor therapy. First, we have found lncRNA CASC7 is a poor prognostic marker of endometrial cancer. Then, ASPN was specifically expressed in endometrium and cell specific expression in basophils, among the most similar genes, we found TGF-&b...
Dalia Zaafar1*, Heba M.A Khalil2, Soha Hassanin3, Mohamed R. Mousa4, Mona G. Khalil1
...uently experience cancer metastasis, relapse, and therapeutic failure despite the use of advanced therapeutic strategies for cancer treatment. As a result, many scientists are currently looking for newly repositioned drugs that can either inhibit cancer proliferation or promote cancer cell apoptosis. Methods: This study examined the effectiveness of pioglitazone (Pio) against mice bearing Ehrlich solid carcinoma in terms of its ability to inhibit cell prolifer...
Lijiao Wang1, Haibin Chen2*, Hongyan Yu1, Zexian Fu3 and Jianjun Zhao2*
...xpression for lymph node metastasis in RCC. Compared with the adjacent tissue, the expression of EPAS-1 in RCC was significantly increased (P < 0.05, χ2 = 4.311). The correlation between the expression of EPAS-1 and primary tumour staging, lymph node metastasis, distant metastasis and the International Society of Urological Pathology (ISUP) grade of clear cell RCC patients were anal...
Quratulain Amjad1,2 and Abdul Rauf Shakoori1,2*
...naling cascades of tumor metastasis. In previous reports it is stated that the interactions between Slit2 and Robo1 are facilitated by heparan sulphate that is abundantly expressed on cell surface and extracellular matrix. Slit2 reduces tumor proliferation in lung cancer and glioblastoma cells whereas TGF-β is a well-described tumor inducer. The present study was aimed at deciphering the role of heparan sulphate in Slit2 mediated inhibition of cancer
Wenfeng Lin1* and Qiqi Zheng2
...he role of KIF20B in the metastasis of colon cancer cells. CCK-8 method and Transwell cell test were used to determine the proliferation, invasion, and migration of cells. Western blotting was used to determine the changes in expressions of vimentin ZO-1, E-cadherin, β-catenin, N-cadherin and Gli1. We found that at 48h~96h, compared with the control group, the proliferation ability of the group with overexpression of KIF20B was significantly increased (P&...
Hu-Hu Chen1,2, Xin Li2,3, Mohd Hijaz Mohd Sani2 and Siat Yee Fong2,4*
Fang Li1, Na Zhao1, Dan Wu1, Jingya Hei2 and Yuyang Pan1*
...our diameter and whether metastasis was a relevant factor affecting the diagnostic efficacy of cytology smear combined with frozen section, and in the multivariate logistic regression analysis, tumour diameter and whether metastasis was an independent risk factor affecting the pathological diagnostic efficacy of cytology smear combined with frozen section. The application value of cytology smear combined with frozen section ...
Zuhair M. Mohammedsaleh1*, Mamdoh S. Moawadh1, Fayez M. Saleh2, Mohammed M. Jalal1, Abdulaziz S Al-Otaibi1, Nizar H. Saeedi1, Rathinasamy Baskaran3, Chih-Yang Huang4 and V. Bharath Kumar5*
...erformed to evaluate the metastasis and western blot to check the protein expression. The results showed that the combination of CXB and Cis synergistically inhibited cell proliferation, migration and invasion of OC-3 cells. The notch signalling pathway plays an oncogenic role in tongue squamous cell carcinoma. We observed that treatment with CXB and Cis decreased NOTCH1, JAG1, Pre 2, and ADAM9 expression and increased Numb protein expression. Our study demons...
