Acute Oral Toxicity and Neurobehavioral Effects of Salvia officinalis Essential Oil in Female Wistar Rats
Safaa Rhaimi1, Sara Brikat2, Mouloud Lamtai2*, Mohammed Ouhssine1
1Laboratory of Agro-Physiology, Biotechnology, Environment and Quality, Faculty of Science, Ibn Tofail University BP, 133-14000, Kenitra, Morocco; 2Laboratory of Genetics, Neuro-Endocrinology and Biotechnology, Department of Life Sciences, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
*Correspondence | Mouloud Lamtai, Laboratory of Genetics, Neuro-Endocrinology and Biotechnology, Department of Life Sciences, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco; Email: mouloud-lamtai@hotmail.fr
Figure 1:
Salvia officinalis plant.
Figure 2:
Changes on the body weights during 14 days of observation in male rats after single oral treatment of S. officinalis essential oil.
Figure 3:
Food consumption expressed in g/d (a) and Water intake expressed in ml/d (b) of female rats orally administered with S. officinalis essential oil.
Figure 4:
(a) Total amount time spent in the center (TCA). (b) Number of returns into the center area of the arena in the open-field behavior apparatus (NRC). (c) Number of total squares (NTS) in the open field test in female rats after the administration of 1000 mg/kg of S. officinalis essential oil. Data are represented as mean ± S.E.M. *p < 0.05 vs. control group.
Figure 5:
(a) Total amount of time spent in open arms (TOA). (b) Number of entries in open arms (EOA) in the EPM test in female rats after the administration of 1000 mg/kg of S. officinalis essential oil. Data are represented as mean ± S.E.M. *p < 0.05 vs. control group.
Figure 6:
Immobility time expressed in seconds (Sec) (TIM), in the forced swimming test in female rats after the administration of 1000 mg/kg of S. officinalis essential oil. Data are represented as mean ± S.E.M. *p < 0.05 vs. control group.
Figure 7:
Effect of oral administration of S. officinalis essential oil (1000 mg/kg) on spontaneous alternation percentage measured in Y-maze. Data are represented as mean ± S.E.M. *p < 0.05 vs. control group.
Figure 8:
Effects of S. officinalis essential oil (1000 mg/kg) on recognition memory measured in the object recognition test. Data are represented as mean ± S.E.M. *p < 0.05 vs. control group.