Assessment of Oxidative Stress Biomarkers and DNA Damage Among Pesticide Retailers in South Punjab, Pakistan
Assessment of Oxidative Stress Biomarkers and DNA Damage Among Pesticide Retailers in South Punjab, Pakistan
Abdul Ghaffar1*, Maria Niaz1, Ghulam Abbas2, Riaz Hussain3, Fozia Afzal4, Habiba Jamil1, Ahrar Khan5,6, Rabia Tahir7, Muhammad Ahmad Chishti1, Shahnaz Rashid3, Shahzad Ali Gill8, Aliya Noreen9, Ayesha Maqsood1 and Kashfa Akram1
ABSTRACT
This study was conducted to explore the hazardous effects of pesticides on the pesticide exposed retailers. For this purpose, blood of total 100 pesticide workers of different age groups were sampled in different areas of district Khanewal Punjab, Pakistan. Comparison was made with 100 non-exposed persons. Analysis of blood samples was done with the help of hematological analyzer and serum collected in this study was use for different biochemical tests. Hematological parameters including HGB, RBCs count, hematocrit, MCV, MCHC, monocytes, lymphocytes, neutrophils and eosinophils vary in different diseases in the exposed and unexposed workers. The percentages of occurrence of certain diseases were high in exposed group than the unexposed groups. Biochemical parameters ALT, AST, LDH, CPK, ALP, Creatinine, urea, lipid profile tests, and tests of certain minerals showed variations of values in different diseases. The comet assay is used to check the DNA damage in lymphocytes of both exposed and unexposed groups. The pesticide exposed group has significantly high values of DNA damage as compared to the unexposed group. Therefore, it is concluded that pesticide exposure causes oxidative stress and DNA damage in the workers dealing with pesticides.
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