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Crimean-Congo Hemorrhagic Fever Virus: Advanced Insights into Virology, Pathogenesis, Pathology, Diagnosis, and Treatment

Crimean-Congo Hemorrhagic Fever Virus: Advanced Insights into Virology, Pathogenesis, Pathology, Diagnosis, and Treatment

Muhammad Sajid1*, Muhammad Hamid2, Usama Ayyub2 and Muhammad Azam2 

1Faculty of Veterinary Sciences, University of Agriculture Faisalabad, Pakistan; 2Department of Allied Health Professionals, Faculty of Life Sciences, Government College University Faisalabad, Pakistan. 

 
*Correspondence | Muhammad Sajid, Faculty of Veterinary Sciences, University of Agriculture Faisalabad, Pakistan; Email: msajidkhan663@gmail.com 

ABSTRACT

The Crimean-Congo hemorrhagic fever virus (CCHFV), which causes causative agent Crimean Congo hemorrhagic fever (CCHF, is a tick-borne illness that can cause various symptoms, from non-symptomatic infection to deadly viral hemorrhagic fever. More than 30 nations have reported cases of the disease recently. To provide a general understanding of the virology, etiology, pathophysiology, diagnostic testing, and diagnostics, and antiviral treatment of CCHF, we provide a critical reviewed of the literature. The chemical interactions and life cycle of viruses are intricate and are poorly understood. Despite our limited understanding of pathogenesis and immunobiology, multiple routes contribute to the viral entry, replication, and clinical damage. A few autopsy reports have highlighted mention hemorrhages and extravasation involving many body organs. A deeper comprehension of the pathophysiology and immunology of the CCHFV virus will enhance patient care and hasten the creation of CCHF medication countermeasures. Physicians We anticipate that physicians should familiarize themselves with the instruments available for managing and diagnosing human CCHFV infections in human.

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Pakistan Journal of Zoology

October

Pakistan J. Zool., Vol. 56, Iss. 5, pp. 2001-2500

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