Crimean-Congo Hemorrhagic Fever Virus: Advanced Insights into Virology, Pathogenesis, Pathology, Diagnosis, and Treatment
Crimean-Congo Hemorrhagic Fever Virus: Advanced Insights into Virology, Pathogenesis, Pathology, Diagnosis, and Treatment
Muhammad Sajid1*, Muhammad Hamid2, Usama Ayyub2 and Muhammad Azam2
ABSTRACT
The Crimean-Congo hemorrhagic fever virus (CCHFV), which causes causative agent Crimean Congo hemorrhagic fever (CCHF, is a tick-borne illness that can cause various symptoms, from non-symptomatic infection to deadly viral hemorrhagic fever. More than 30 nations have reported cases of the disease recently. To provide a general understanding of the virology, etiology, pathophysiology, diagnostic testing, and diagnostics, and antiviral treatment of CCHF, we provide a critical reviewed of the literature. The chemical interactions and life cycle of viruses are intricate and are poorly understood. Despite our limited understanding of pathogenesis and immunobiology, multiple routes contribute to the viral entry, replication, and clinical damage. A few autopsy reports have highlighted mention hemorrhages and extravasation involving many body organs. A deeper comprehension of the pathophysiology and immunology of the CCHFV virus will enhance patient care and hasten the creation of CCHF medication countermeasures. Physicians We anticipate that physicians should familiarize themselves with the instruments available for managing and diagnosing human CCHFV infections in human.
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