Effect of Human Recombinant Activated Coagulation Factor VII (rFVIIa) on Total Bleeding Volume and Coagulation Function of Patients
Effect of Human Recombinant Activated Coagulation Factor VII (rFVIIa) on Total Bleeding Volume and Coagulation Function of Patients
Xiaolei Yan, Yabing Tang and Sainan Hu*
ABSTRACT
The aim of this study was to analyze the effect of human recombinant activated coagulation factor VII (rFVIIa) on total bleeding volume and coagulation function of patients with postpartum hemorrhage (PPH). A total of 80 patients with PPH in Hunan Provincial Maternal and Child Health Care Hospital, intensive care unit (ICU), were recruited and assigned into an experimental group (EG) and a control group (CG). The results revealed that conservative treatment in the EG were considerably superior to those of the CG, while interventional embolization of arteries, surgical artery ligation, and hysterectomy were greatly inferior to those of the CG. The bleeding volume of patients in the EG was 2.18±0.14 L, while that of patients in the CG was 3.35±0.49 L. The bleeding volume of patients in the EG was evidently inferior to that in the CG. The patients in the EG had markedly inferior prothrombin time and activated partial thromboplastin time after medication but superior fibrinogen level versus the CG. Furthermore, the total effective rate of patients (82.5%) in the EG was substantially superior to that of the CG (65%). It was concluded that rFVIIa can effectively improve maternal coagulation function, reduce the possibility of surgical intervention, and reduce PPH.
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