Effect of Platelet-Rich Fibrin Combined with Guided Bone Regeneration on Bone Formation of Peri-Implant Bone Defects
Effect of Platelet-Rich Fibrin Combined with Guided Bone Regeneration on Bone Formation of Peri-Implant Bone Defects
Li Yang1, Xuliang Ma2 and Chao Wang1*
ABSTRACT
Platelet-rich fibrin (PRF) combined with guided bone regeneration (GBR) is an emerging treatment method. The purpose of this study was to demonstrate the effects of PRF on the osteogenic ability of peri-implant bone defects. The sample of 67 patients who needed dental implants in Hebei Provincial Eye Hospital from March 2021 to March 2022 were randomly grouped: experimental group (immediate implant placement + implant covering PRF, n=40) and controls (immediate implant placement, n=27). The patients were followed up for 6 months to evaluate the treatment effect. The osteogenesis ability of the two groups at different time points and the state indicators around the implant before and after treatment were observed. At different time points after operation, the bone width and bone height in experimental group were higher as against controls (P<0.01). The level of bone resorption in experimental group was higher as against controls (P<0.05). There was no significant difference between two groups before treatment (P>0.05). The plaque index, sulcus bleeding index, probe bleeding index, and periodontal probe depth in experimental group were better as against controls (P<0.01). It was concluded that the use of PRF plus GBR in the treatment of patients with bone defects in periodontal disease can greatly reduce the adverse reactions of patients, effectively improve the periodontal status indicators, and shorten the recovery period of the disease.
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