Effects of Desflurane on Inflammatory Response and Cardiac Function During Cardiopulmonary Bypass in Cardiac Surgery
Effects of Desflurane on Inflammatory Response and Cardiac Function During Cardiopulmonary Bypass in Cardiac Surgery
Jingjing Guo, Ruitong Niu, Shanshan Mu* and Anshi Wu
ABSTRACT
The objective of this study was to investigate the effect of desflurane on inflammatory response and cardiac function during cardiopulmonary bypass in cardiac surgery. Thirty adult male Sprague-Dawley rats (body weight, 250-300g) were purchased from the Provincial Academy of Agricultural Sciences, and the rats were housed in a specific pathogen-free facility and maintained under controlled conditions. The rats were divided into control group (CG), surgical model group (SMG) and desflurane group (DG). The level of circulating mtDNA and the mRNA expressions of interleukin 6 (IL-6), Tumor necrosis factor α (TNF-α) and IL-1β were detected by RT-PCR. Organ damage during extra corporeal circulation (ECC) was compared by histopathological analysis. Compared with the CG, the mtDNA level in the SMG was higher (P<0.05), and the mtDNA level in the DG was lower than that in the SMG (P<0.05). The mRNA expressions of IL-6, TNF-α and IL-1β in the SMG were higher than those in the CG (P<0.05). The mRNA expressions of IL-6, TNF-α and IL-1β in the DG were lower than those in the SMG (P<0.05). It was found that the use of the volatile anesthetic desflurane in the rat cardiac surgery model can significantly reduce the levels of inflammatory factors in cardiopulmonary bypass, inhibit myocardial cell apoptosis and oxidative stress, and improve cardiac function.
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