Rana Muhammad Aadil1,2*, Xin-An Zeng1, Saqib Jabbar3, Akmal Nazir2, Abid Aslam Mann2, Muhammad Kashif Iqbal Khan2, Abdullah2, Amna Ramzan2
...ue, hunter color values, bioactive compounds, microorganisms and enzyme analysis. The grapefruit juice was treated with processing variables of HPP treatment (0, 150, 200 and 250 MPa), temperature (40, 50 and 60 oC), for processing time of 3 minutes and thermal treatment was done in a water bath at 70 oC for 90 seconds. In HPP treatment (250 MPa/60 °C/3 min), significant reduction was observed in microorganisms, PME and PPO whereas im...
Shazia Erum*, Muhammad Naeemullah and Shahid Masood**
Corresponding author: [email protected]
PHENOTYPIC VARIATION AMONG MENTHA SPP.
... the presence of diverse bioactive compounds and essential oils. The present study may help to patronize the essential oil industry on latest scientific techniques. Like other herbs Mentha have diverse aromatic properties that can be explored for utilization in the industry and this information will be helpful for exploitation and development of natural agricultural resources on scientific grounds....
Nimra Naseer, Adeela Fatima and Imran Sajid*
...ally for their potential bioactive secondary metabolites against MDR bacterial pathogens. The identification of strains was done by morphological, physiological and biochemical characterization and by 16SrRNA gene sequencing. For biological screening different methods including cross streak, agar plug and well diffusion method were performed. Seven Streptomyces strains including NWMD-6, NWMD-7, NWMD-10, NWMD-11, NWMD-12, NWMD-15 and NWMD-16 were found t...
Muhammad Khan
...on and validation of new bioactive molecules. Proscillaridin A (PSD-A), is a natural cardiac glycoside molecule used to treat cardiac arrhythmia. Recently, it has been rediscovered for its potential anticancer activity. This review will mainly focus on the anticancer activity, cellular targets and anticancer mechanism of PSD-A which may help the further design and conduct of research and repositioning it for oncological clinic.
...
Syed Atif Hasan Naqvi1*, Ummad-ud-Din Umar1, Ammarah Hasnain2, Ateeq ur Rehman1 and Rashida Perveen1
...were investigated as the bioactive eco-friendly compounds, and as the possible alternatives to hazardous chemicals for the control of BLB of rice. Aqueous extracts of fifteen different plant parts either individually or in combination were tested at various concentrations under in vitro conditions by poison food and disk diffusion techniques while best effective seven were trialed in glass house and field experiments to determine their efficacy against Xanthom...
Dilara Abbas Bukhari1, Abdul Rehman2*
Isolation of bioactive compounds from exudate of edible fungus, Pleurotus ostreatus
...ed at to investigate the bioactive compounds from exudate of a fungus, Pleurotus ostreatus. Exudate as liquid droplets on the mycelium was checked for antimicrobial activity against bacterial strain, Bacillus subtilus. Biochemical techniques, thin layer chromatography, high performance liquid chromatography and gas chromatography/mass spectrometry, were employed to study fungal exudate. A total of fifteen different metabolites were detected in the sample by GC...
Shaukat Ali1,*, Sundas Nasreen1, Sobia Safeer1, Saiqa Andleeb1, Mubashir Ejaz1, Saira Bano2, Hafiz Abdullah Shakir3
Medicinal plants as therapeutic agents for cancer treatment
...r />
of anticancer lead bioactive molecules such as vinca alkaloid, vinblastine, vincristine, camptothecin, and taxanes
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and traditional pharmacology is reemerging
to caring good base as striking discovery train. The current declined in the number of new ...
have been characterized from different medicinal plants and are used as therapeutic agents in worldwide. Technical
strategies based on the natural yield of drug innovation, ethnomedicines and traditional pharmacology is reemerging
to caring good base as striking discovery train. The current declined in the number of new ...
Sana Aslam1, Wayne Thomas Shier2 and Imran Sajid1*
... and to characterize the bioactive metabolites produced by them. A total of seventy strains of actinomycetes were isolated from lake samples, out of them only forty bioactive strains were selected for further characterization on the basis of their preliminary antimicrobial activities. The isolated actinobacterial strains showed an optimum growth at alkaline pH (9.0-9.5). The taxonomic analysis revealed that these isolates we...
Mohammad Ejaz1, Salma Javed2, Muhammad Hamza1, Sadia Tabassum2, Muhammad Abubakar3, Irfan Ullah4*
...nt-size: small;">Natural bioactive molecules or compounds isolated from different living organisms are the rich sources for the novel drugs. Endophytes are the rich source of these bioactive molecules having a wide range of applications as compared to the original products. Fungal endophytes are the most commonly used endophytes for the isolation of various different types of bioactive mol...
Waseem Khalid1, Ali Ikram1*, Muhammad Rehan2, Farukh Adeem Afzal1, Saadia Ambreen1, Marryam Ahmad3, Afifa Aziz1 and Anam Sadiq1
...ded that the presence of bioactive compounds is fully justified by melon seed, including anti-inflammatory agents, hypoglycemic agent, antimicrobial, anti-genic and antioxidant potential.
... 
Bushra Baig and Saeeda Yousaf*
...he study was to find the bioactive compounds in plant extracts of Neem and Black pepper and their effectiveness against reduction in number of whitefly and aphids....
Saima Maher1,3*, Shahina Fayyaz2, Nadra Naheed3 and Zarbakth Dar1
...ematode). The seven pure bioactive compounds have been isolated and examined, from which VA 4 and VA7 had a potential effect against M. incognita by showing 90% mortality at 0.1 g/mL after 48 hours of exposure. The LC50 0.0149, 0.1575 μg/ml of (VA4 and VA7), respectively found to be significantly effective than compounds VA5 (LC50 = 0.1575 μg/ml), VA 6 (LC50 =0.1575 μg/ml), VA2 (LC50 = 0.6269μg/ml and VA3 (LC50 = 0.25) VA1(LC50 = 0.3969μg/ml). T...
Arshad Abdulkhalq Yaseen1,2* and Mária Takácsné Hájos1
...significantly impact the bioactive compounds as total polyphenols and vitamin C. However, the treatment of 6% MLE significantly reduced nitrate content in the plant leaves of both experiments by 4% in 2019 and 20% in 2020. In both experiments, the significantly influenced factors on the bioactive compounds (total polyphenols and vitamin C) were mainly due to the plant varieties and the interaction of 6% MLE and plant varieti...
Bingjie Zhou1, Hitesh Bhagavanbhai Mangukiya1, Siva Bharath Merugu1, Fakhar-un-Nisa Yunus1, Yuchen Fan1, Zhenghua Wu1,* and Dawei Li1,2,*
...l function of AGR2. This bioactive and auto-fluorescent his-tag recombinant AGR2-DsRed (hAD) protein was constructed by linking human AGR2 C-terminus with the red fluorescent protein derived from Discosoma sp. (DsRed) througha flexible linker. It was expressed successfully in Escherichia coli (E. coli) with optimized strain and cultivation parameters. This protein was expressed and purified by Nickel-nitroacetic acid (Ni-NTA) affinity chro...
Muhammad Hamza Tariq1, Mahjabeen Akram2 and Yasir Sharif3*
Stefan Pratama Chandra1, Yoanes Maria Vianney1, Theresia Liliani Christie2, Merlyn Wongso2, Melisa Widjaja2, Deok-Chun Yang3, Se Chan Kang4, Manar Fayiz Mousa Atoum5,6 and Johan Sukweenadhi1*
...l medicine that contains bioactive compounds called ginsenosides. It is widely used as raw material in many pharmaceutical industries in Indonesia. However, to supply for this purpose, they still rely on imports. PT. Kalbe Farma (through its subsidiary, PT. Bintang Toedjoe), University of Surabaya (Ubaya), and Hanbang-Bio Laboratory (holding company of Kyung Hee University) established the Kalbe Ubaya Hanbang-Bio Laboratory (KUH Lab), a collaboration initiated...
Lethal and Sub Lethal Effects of Plant Extracts and Green Silver Nanoparticles against Culex pipiens
Abdul Jabbar1, Muhammad Tariq1*, Asim Gulzar1, Tariq Mukhtar2 and Tayyaba Zainab3
...on as potentially useful bioactive compounds against mosquitoes. In the present study, the effects of extracts of four plants i.e. Azadirachta indica, Zingiber officinale, Syzygium aromaticum and Datura stramonium and their green synthesized silver nanoparticles (AgNPs) were evaluated against 3rd and 4th instar larvae of C. pipiens. The green synthesized AgNPs of these plants were characterized by UV-Multiskaner. LC20 and LC50 values were calculated through Pr...
Hanan Fathy Hammouda1, Mohammad Mahmoud Farag2*, Mervet M.F. El Deftar3, Mohamed Abdel-Gabbar4, Basant M. Mohamed4
...valuate cerium-doped nanobioactive glass/collagen/chitosan composites scaffolds with osteoblast mineralization of normal rabbit bone marrow mesenchymal stem cells (rBM-MSCs) and cancer osteosarcoma cells. The non-cellular in vitro bioactivity test was performed in simulated body fluids for periods 1, 3, 10, 20 and 30 d by measuring the calcium and phosphate ion concentrations by SEM/EDX analysis. While, the bioactivity of expanded and differentiated ost...
Ilvir Khabibullin1*, Ruzel Khabibullin1, Irina Mironova1, Lyalya Musina2, Elmira Akhmadullina1, Victoria Morozova1
... experiments showed that bioactive supplements of different nature optimized the homeostasis of the laboratory animals. It positively affected their skeletal and heart muscles, lung tissue, liver and kidneys, where immunity and blood cells develop. Although the swimming test at the beginning of the experiment showed that mice and hamsters had approximately the same indicators of physical endurance, by the end of the experiment, the swimming time of the experim...
Rabia Bibi1, R. Muhammad Tariq2, Samir A.M. Abdelgaleil3 and Munawwer Rasheed1, 4*
...re enriched with natural bioactive compounds have been utilized in the current study to alleviate the stored grain pests infestation. Four species of red seaweeds Asparagopsis taxiformis, Laurencia karachiana, Gracilaria foliifera, and Jania rubens found abundantly along the Karachi coast, Pakistan were collected in the year 2015-18. Samples were extracted using a Soxhlet extraction method with solvents of varying polarity (hexane, dichloromethane, and methano...
Nabila Khan1, Imran Ahmad2 and Muhammad Bilal Sadiq1*
Iram Liaqat1*, Umaima Bibi2, Muhammad Arshad3 and Najma Arshad2*
...r isolation of potential bioactive components with natural and inherent antimicrobial and antioxidant properties....
Widiastuti Ardiansyah1,3*, Osfar Sjofjan2, Eko Widodo2, Suyadi Suyadi2, Danung Nur Adli2
.... The turmeric consisted bioactive substances, while Lactobacillus sp. produced lactic acid bacteria. The 280 laying ducks used were Mojosari ducks aged 20–28 weeks reared for eight weeks on the experimental diet. The Curcuma longa flour used was produced by Balai Materia Medika, Batu District and the liquid probiotics used contained Lactobacillus sp. bacteria in concentration of 1.4 x 1010 CFU/ml. A completely randomized design with six treatments and f...
Mohamed E. El-Speiy1, Tarek A. Sadak1, Mohamed A. Abd-Elaal1, Ayman M. Khalifah2, Amr S. Morsy2*
Aiman Al-Mufarji1, Abd El-Nasser Ahmed Mohammed1*, Haitham Al-Masruri2, Rashid Al-Zeidi3
...mins, pigments and other bioactive compounds”. The microalgae composition varies depending on species and nutrient availability for production. Genetic engineering might be used for production invaluable microalgae compounds. Microalgae consider a promising source of omega-3 fatty acids (n-3 FAs), which have beneficial effects for humans and animals. Knowledge for microalgae effects on productive, reproductive and therapeutic performances is more fragmen...
Samina Kausar1, Rana Badar Aziz2, Muhammad Waseem3, Muhammad Ahmad3, Hamza Shafiq4, Muhammad Asim5, Usama Zia6, Sobia Afzal7, Wanpeng Xi8*, Mansoor Hameed1* and Muhammad Usman Shoukat9
...n redness. Lycopene is a bioactive component regarding the remedy of persistent sicknesses and lowering the chance of cardiovascular illnesses or cancer. The tremendous results of carotenoids in human food have prompted numerous efforts in plant genetic engineering to supply products with greater carotenoid accumulation, which isn’t always only beneficial for agriculture but also has consequences for scientific research in terms of organic, chemical, and...
Widiastuti Ardiansyah1,3, Osfar Sjofjan2*, Eko Widodo2, Suyadi Suyadi2, Danung Nur Adli2
...y aimed to determine the bioactive compound of turmeric and its effects on the reproductive organs of Mojosari ducks. A total of 500 grams of turmeric were prepared for the identification of bioactive compounds and flavonoids, while a total of 280 Mojosari ducks aged 20–28 weeks were used in the second step. The study comprised a descriptive analysis and a completely randomized design with six treatments and four repli...
Irshad Ahmad1,2*
...also its unique array of bioactive compounds can improve coloration and quality of fillet. The aim of this review is to provide an update of the current knowledge of microalgae as a supplement or feed additive to substitute FM and FO in aquafeeds. This review will provide a platform to highlight the potential of microalgae-based aquafeeds for a sustainable aquaculture industry....
Hafiz Husnain Nawaz1*, Ayesha Ahsan2, Amir Afzal1, Muhammad Ashraf Sumrah1, Muhammad Jan1, Kashif Ali1, Muhammad Arsalan1 and Rizwan Latif3
Amir Abdullah Khan and Muhammad Irfan*
...on for the production of bioactive compounds. Various parameters were optimized to obtain maximum bioactive compounds production. Maximum antifungal activity was observed at temperature 37°C, pH 8, inoculum size 2.5% and 24h fermentation period. These results recommended the potential utilization of Bacillus subtilis 2i for intention to control the disease causing fungus Schizophyllum sp. B2A in citrus.
T.S. Rizvi and F. Shahina†
...cynthis contains various bioactive compounds. The mentholic
extracts of seed had the highest mortality (100%) at highest exposure time (72 hrs) while, the pulp and fruit extracts
showed 60 and 80% mortality, respectively. Among various extracts of creeper hexane extract (HH-CC) showed
100% mortality after 72 hrs at all concentrations as compared with standard carbofuran. Whereas, HE-CC and HWCC
showed 100% mortal...
Rukhsana Anwar1*, Ammara Abd-Us-Sattar1, Afifa Noor2, Kanwal Ashiq1,3 and Shah Jahan4
...esence of many important bioactive compounds. Real-time PCR results showed that aqueous extract decreased the mRNA expression of CYP1A2, CYP3A4. The methanolic extract decreased mRNA expression of CYP2C9 and CYP3A4. Both extracts enhanced GST-specific activity, tGSH, SOD, and CAT activity in rats. It is concluded that leaf extracts of C. oppositifolia showed significant interaction with drugs. This can modulate drug-metabolizing enzyme activity and reduce oxid...
Bashir Ahmad1*, Ali Muhammad Yousafzai2, Waqar Ali1, Ikram Ilahi1, Farman Ullah3, Saeed Ahmad1, Ayaz Ali Khan1, Umair Ahmad2 and Hafsa Maria2
...s needed to identify the bioactive ingredient and determine the effectiveness of this herbal substitute....
Yusri Sapsuha1*, Nur Sjafani1, Suryati Tjokrodiningrat2
...nclusion, cloves contain bioactive substances that can be used to improve broiler chicken performance and health. Administration of appropriate dose is believed to replace the role of AGP, which is currently prohibited from its use in broiler chicken feed.
Keywords | AGP, Broiler, Cloves, Health status, Performance
...
Ferzana Bhatti1, Fiaz Hussain2, Zain ul Abdin1*, Muhammad Arshad1, Saqi Kosar Abbas2 and Muhammad Zeeshan Shabbir3
...helpful to explore novel bioactive molecules useful for sustainable insect biological control programes, especially from the insect parasitoids of Pyralidae (Lepidoptera)....
Noor Rahmawati, Alfi Rumidatul* and Sopandi Sunarya
...ophytic fungi to produce bioactive compounds that have antibacterial and antioxidant activity. The method used in this study was to ferment endophytic fungi from gall rust sengon in different media, namely PDB, PDB plus sengon wood powder, and PDB plus yeast, for 9 days, followed by extraction using ethyl acetate solvent and testing of antioxidant and antibacterial activity. The DPPH radical was used to measure antioxidant activity, and Bacillus subtillis was ...
TAHIR MEHMOOD*, ANUM AFZAL, ABDUL KARIM, MUHAMMAD ASHRAF SHAHEEN &
HINA ARSHAD
Rahma Boukarine*, Leila Hamdi and Kamel Khelili
... human diseases. Several bioactive compounds have been extracted from plants and fruits, especially antioxidants which aid protect against oxidative stress. This study was conducted on Albino Wistar rats to investigate the antioxidant effect of Eruca sativa on the hepatic and renal profile damaged by xylene. Seventy rats were divided into seven equal groups and treated by gavage for 30 days as follows: Control group (C), group (CO), positive control group (RE)...
Hamdi Mayulu1*, Endang Sawitri2
...es, and organoleptic and bioactive compounds in garlic. Therefore, this study aims to investigate the phytochemical potential and antioxidant capacity of black garlic as a livestock feed additive. The Folin-Ciocalteau method was used to test for tannins and total phenolics, and the aluminum chloride (AlCl3) method was used to assess flavonoid content. In addition, antioxidant capacity was determined with Radical Scavenging Activity 2,2-diphenyl-1-picrylhydrazy...
Amina Rahat1, Zahin Anjum1*, Sehlina Zehra2, Fatima Umal Baneen3 and Rabia Chishti1
... medicinal plants. These bioactive chemicals serve as a foundation for the creation of antibiotics that are utilized to cure infectious illnesses. Allium sativum is being used traditionally since ages for many purposes. It is extensively used in numerous dishes throughout the world and due to its aromatic nature, as a fragrance and Plantago ovata is traditionally used for many therapeutic purposes; laxative anti-acidic stabliser, stomach soothing, diuretic; an...
Iram Liaqat1*, Noor Muhammad1, Muhammad Mubin2, Najma Arshad3, Tehreema Iftikhar4, Sumera Sajjad5 and Farzana Rashid5
...ns thus confirming their bioactive potential. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of screened Actinomycetes was in the range of 1.3 - 3.5 mgmL-1 and 1.9 – 4.0 mgmL-1 of bacterial biomass, respectively. Three isolates, S. monticola, S. septentrionalis and S. polaris showed 100 % mortality at 1000 ppm against Anopheles 3rd instar larvae. These findings indicated that actinobacterial isolates possess antib...
Reza Esmaealzade Dizaji1, Arasb Dabbagh Moghaddam1*, Arash Ghalyanchi Langeroudi2, Mohamad Foad Heydari3, Seyyed Javad Hosseini Shokouh4 and Ana Shirzad Shahrivar5
..., topical application of bioactive nano-glass fibers (BNF) loaded with platelet-rich plasma (PRP) was used to examine the effects on a second-degree heat wound and the healing process’ sub-streaming molecular route for re-epithelialization. Model (deep second-degree thermal wound), PRP, and PRP/BNF groups were each randomly assigned a set of animals. Wounds were monitored daily for many days following therapy to see how they were healing. H&E stainin...
Aamir Ali, Hafiz Muhammad Tahir*, Azizullah, Shaukat Ali, Muhammad Farooq Bhatti, Muhammad Summer and Ali Haidar Gormani
...ts and contain different bioactive substances including flavonoids, phenols and alkaloids. Mulberry leaves extracts have also shown significant pharmacological activities including anti-inflammatory, antioxidant, antibacterial, anticancer, anti-diabetic and antidepressant activities. Further studies should explore the mulberry leaves potentials as these plants have got the attention of both the pharmacological and commercial industries.
Siddique Ahmad1*, Basit Ullah1, Sajid Ali2, Ali Zaid1, Zeeshan Ahmad3, Muhammad Usaid1, Muhammad Zeeshan1 and Saif Ullah3
...leic acids, lactic acid, bioactive substances, hormones, enzymes and sugars. All these substances promote active cell and root division, plant growth, productivity, suppress harmful microorganisms, and enhance the decomposition of organic matter. Results showed that integrated use of PM and N (120 or 160 kg ha-1) along with the application of bio-aab significantly (P≤0.05) improved tillers m-2 (12%), grains spike-1 (15%), biological yield (31%) and grain yi...
Fatemeh Beheshti1, Maliheh Safavi2, Mohammad Reza Akbari Eidgahi1,3, Parviz Kokhaei4, Mehdi Vazirian5 and Ali Akbar Shabani1,3*
...uted to the existence of bioactive molecules and provide additional data for future research....
Hafiza Mehwish Iqbal1, Salman Khurshid1*, Saqib Arif1, Qurrat-ul-Ain Akbar1, Saba Iqbal2, Shahid Yousaf3, Kainat Qureshi1, Abdul Karim Khan5, Abdul Ahad6, Aqeel Ahmed Siddique4 and Neelofar Hamid7
Khansa Jamil1, Muhammad Ramzan Khan1, Asad Jan2 and Ghulam Muhammad Ali1*
...tandard gentamycin. Four bioactive compounds were subjected to molecular docking from which all targeted compounds received scores ranging from (−3.5 to −5.9) kcal/mol with targeted protein. Hence the study revealed that bioactive compounds derived from the Caralluma tuberculata plant pose highly antibacterial activity and might be used to synthesize the antibacterial drug....
Wisit Ketpanyapong1, Kulisara Marupanthorn2*
...edicine for its multiple bioactive components beneficial to animals and humans. However, the effects of Moringa oleifera leaf extract (MOLE) supplementation on growth performance and intestinal morphology in weaned pigs are poorly understood. This study examined the effects of MOLE supplementation (250 mg/kg or 500 mg/kg diet) on 144 Duroc × Landrace × Large White weaned pigs over a 5-week period. The results of this study showed that dietary suppl...
Pramudya Andiana*, Moch. Geerhan Miraja Syahdan, Khothibul Umam Al Awwaly, Abdul Manab
Feri Eko Hermanto1, Yuli Frita Nuningtyas1, Filoza Marwi1, Fajar Shodiq Permata2, Agus Susilo1, Muhammad Halim Natsir1*
...omodulatory potential of bioactive compounds found in these herbs. Biological networks were constructed for gut health and mucosal immunity, focusing on common proteins to identify promising targets. Our analysis pinpoints Interleukin-6 (IL-6) as the central protein governing gut health and mucosal immunity. Further exploration reveals that several bioactives, primarily from Teak Leaves and Ginger, form tight interactions wi...
Kiran Rani1*, R. Aliya1, Barkat Ali Solangi2, M. Kashif Pervez2, Nasrullah Akhtar3 and Farman Ahmed4*
...ement were examined. The bioactive efficiency of seaweed extract and dyed fabric were also investigated against human pathogens such as Escherichia coli, Staphylococcus aureus and Candida albicans and were compared with commercial antibacterial and antifungal drugs. It was found at the optimized dyeing condition has 1 percent formic acid as fixing agent with 120 min dyeing period. At this condition, the dye molecule shows 70 percent exhaustion and 59 percent f...
Syeda Fakehha Naqvi1, Iqra Haider Khan1 and Arshad Javaid1
*Arshad Javaid1, Syeda Fakehha Naqvi1 and Iqra Haider Khan1
... this study,
bioactive compounds present in ethyl acetate fraction of root extract of C. murale were
identified. The weed plants were collected from Jehlem, Pakistan. Its roots were dried,
powdered and extracted in methanol. After evaporation of the solvent, the remaining
extract was mixed in water and partitioned with n-hexane, chloroform and finally with ethyl
acetate. The last fraction was analyzed...
*Malik F. H. Ferdosi1, Arshad Javaid2, Iqra Haider Khan2, Muhammad F. A. Fardosi3 and Ayesha Munir4,5
...rder to find out various bioactive compounds in flowers of Ageratum conyzoides, the dried powdered flowers were extracted in methanol and the extract was examined by GC-MS. In total, eight constituents were identified in the extract. The predominant compound in the methanol flower extract was precocene II (59.50%). Three moderately abundant compounds including ethanone, 1-(7-hydroxy-5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)- (9.77%), precocene I (8.61%) and...
Murad Ali,AZAZ ALI,MUHAMMAD ADNAN,Zahid Hussain,MURAD ALI KHAN,ABDUL BASIR,KAMRAN AHMAD,MUHAMMAD ANWAR KHAN,NOUMAN SALEEM
Sara Brikat1*, Imane Kherrab1*, Yassine Taaifi2*, Sara Haida3, Laila Ibouzine-Dine1, Oumaima Abouyala1, Ilhame Fitah1, Abdelhalim Mesfioui1, Aboubaker Elhessni1
...for its valuable natural bioactive compounds. This study aims to investigate the acute toxicity, antidepressant effects, antioxidant activities, and memory enhancement potential of methanolic extract of Curcuma longa (MECL) in high fructose-treated rats. To assess acute toxicity, rats were divided into five groups treated with different doses of MECL (2000, 3000, and 4000 mg/kg) for 14 days. For the evaluation of antidepressant, antioxidant activities and memo...
Hafsa Tauqir1, Imran Ahmad2 and Muhammad Bilal Sadiq1*
...s a potential source for bioactive compounds with strong antimicrobial activity and antioxidant activity. The purpose of the study was to determine the total phenolic content (TPC), antioxidant content and betalain content of beetroot pomace extract (BPE) under optimized extraction conditions. Beetroot pomace was further used to develop a flavored yogurt. The highest responses for DPPH inhibition (66.6%), betaxanthins (174 mg/L), betacyanins (265 mg/L) and TPC...
*Arshad Javaid1, Iqra Haider Khan1 and Malik F. H. Ferdosi2
Malik F. H. Ferdosi1, Iqra Haider Khan2, Arshad Javaid2*, Hafiz Muhammad Saeed1, Ifrayeem Butt2 and Ayesha Munir3
Arshad Javaid1*, Malik F. H. Ferdosi2, Iqra Haider Khan1, Amna Shoaib1, Hafiz Muhammad Saeed2, Muhammad Abrar Ul Hassan1
...entification of possible bioactive compounds. α-Amyrin was the major compound (32.49%) followed by lup-20(29)-en-3-ol, acetate, (3β)- (25.72%). Moderately abundant compounds included γ-sitosterol (8.78%), β-amyrone (7.25%), cyclohexane, 1,3,5-triphenyl- (7.01%), olean-12-en-3-ol, acetate, (3β)- (5.68%), and n-hexadecanoic acid (3.18%). Some of the identified compounds have various important biological properties including anti-inflam...
Suherman Suherman1*, Muhammad Fahri Rizky1, Zaki Bahrul Fikri1, Hadiyanto Hadiyanto1, Zane Vincevica-Gaile2, Anwar Saeed Khan3, Erkata Yandri4,5 and Iswahyudi Iswahyudi6
...temperature analysis and bioactive compounds were performed to evaluate the performance of the system in terms of energy efficiency compared to drying in the sun in 8 h. Onions were scattered on trays in the drying room during the experiment. Temperature, relative humidity, sun intensity, and shallot mass were measured every 15 min. The results obtained showing that the fastest drying rate occurs in photovoltaic ventilation solar drying at a temperature variab...
Umair Khatri1, Aijaz Hussain Soomro1*, Shahzor Gul Khaskheli1 and Omer Mukhtar Tarar2
...ess of health-beneficial bioactive metabolites. In recent years, consumers interested regarding fatty acid composition of different food are increasing. This work assessed the nutritional value of two different verities of mushrooms including Button mushroom (BM) and Oyster mushroom (OM), and determined the composition and contents of fatty acids. Mushrooms dried in cabinet dehydrator at 55°C for 16 hrs, the obtained mushroom powder packed in an airtight j...
Noor Rahmawati*, Dea Indriani Astuti and Pingkan Aditiwati
...Numerous research on the bioactive elements of secondary metabolites from endophytic microorganisms, particularly endophytic fungi, have been undertaken on plants that are able to produce secondary metabolites with unique properties. When tested using the DPPH radical-scavenging assay, the secondary metabolite Toona sinensis Roem, which was extracted using 80% acetone, shown antioxidant activity. To create antioxidant chemicals, the endophytic fungus T. sinens...
Waqas Ahmad Shams1*, Gauhar Rehman2, Muhammad Ismail3, Rahmul Kabir4 and Abdul Qahar1
... field of marine-derived bioactive compounds.
...
Sana Nawaz1, Shahzor Gul Khaskheli1*, Aijaz Hussain Soomro1, Inayatullah Rajper2, Saghir Ahmed Sheikh3, Ashfaque Ahmed Khaskheli1 and Shaista Soomro1
...the extraction of target bioactive compounds. The review highlights the substantial amount of waste generated throughout the FV supply chain, resulting from inadequate management practices in fields, harvesting, processing, transportation, storage, and distribution. This waste not only represents a loss of food but also leads to degradation of valuable components, including bioactive compounds, with significant implications ...
Sohaila Fathi El-Hawary1, Nermeen M.L. Malak2, Reda A. Gomaa3, Hesham Z. Tawfeuk3, Suzan Ismail4, Nady Khairy Elbarbary5*
Mehak Muhammad Ashfaq1*, Aqsa Naeem Chawla1, Muhammad Umaid Ali1 and Adnan Ahmed Bhutto2
Yusuf Subagyo*, Merryafinola Ifani, Hermawan Setyo Widodo
... phytochemical tests and bioactive identification; however, toxicity, productivity, and milk quality were analyzed by ANOVA, followed by Duncan’s Multiple Range Test. The research showed many active compounds in C. calothyrsus, such as lipids and fatty acids, steroids, triterpenoids, flavonoids, saponins, carbohydrates, and tannins. Few toxic compounds, such as tannins in C. calothyrsus, were not at harmful levels. The ethyl acetate fraction has higher t...
Salim Saifullah1* and Achyut Adhikari2
Roshita Ibrahim1*, Mohd Firza Ahmad Fauzi1 and Mohd Nizam Lani2
...to increased mineral and bioactive compound concentrations compared to other sweeteners. In conclusion, the black jelly drink sweetened with stevia is considered the healthiest due to its low calorie and good functional properties. However, despite these findings, the most favourable black jelly mushroom drink is the one sweetened with sucrose, scoring the highest in aroma, texture, and overall acceptability. The study also suggests the potential of utilizing ...
Nutritional Composition and Sensory Evaluation of Green, Oolong and Black Teas of Sacha Inchi Leaves
Zarinah Zakaria1*, Nur Nabilah Norsham1, Nur Hasyimah Mat Shah1, Nurul Zaizuliana Rois Anwar1, Napisah Hussin2, Fauziah Tufail Ahmad3, Faridah Yahya3 and Norshazila Shahidan4
...e inclusion of important bioactive components. In this study, green tea, oolong tea, and black tea were crafted using a combination of processed Sacha Inchi (Plukenetia volubilis L.) leaves, the traditional tea (Camellia sinensis) leaves and stevia as natural sweetener and also their infusion. The black tea produced contains a high percentage of crude protein, crude fat and crude fibre which is significantly different as compared with green tea a...
Herna Febrianty Sianipar1,2,3, Wahyu Widoretno1, Luchman Hakim1, Rezi Rahmi Amolia4, Fatchiyah Fatchiyah1,2,5*
... amino acids, as well as bioactive compounds with antioxidant activity. Castanopsis argantea, Artocarpus heterophyllus, and Aglaia tomentosa fruits were tested for proximate, amino acid, phytochemical, and total flavonoid content. Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) and the Ferric Reducing Antioxidant Potential (FRAP) method were employed to determine antioxidant activity. Proximate content and amino acid content tests sh...
Mohamed H.M. Abd El-Megid1, A.N. El shahat2, A.M. Abdul Azeem2* and Amal A. Mansour2
...s without destroying its bioactive compounds. In addition, Irr.SSAE is a potent inhibitor of α-amylase and α- glucosidase and has beneficial effects in the treatment of diabetes....
Martina Tri Puspita Sari1, Muhammad Ridla2,3*, Heri Ahmad Sukria2,3
..., contain high levels of bioactive compounds with numerous benefits. This study evaluated Moringa oleifera leaves as a stabilization method to preserve rice bran quality over a 30 days of storage. A randomized block design was employed with ten treatments and four replications: no stabilization with no storage (Control-0) and 30 days of storage (Control-30), heat treatment without storage (Heated-0) and with 30 days of storage (Heated-30), addition of Moringa ...
Afshan Kaleem*, Iqra Noor, Roheena Abdullah and Mehwish Iqtedar
...fiber, carbohydrates and bioactive compounds. They serve as medicinal plants and are used as common food in developing countries. The objective of the current study was to analyze the various biological characteristics of Phaseolus vulgaris and Vigna unguiculata in order to identify new therapeutic leads for specific disorders (colon cancer and memory improvement in Alzheimer’s disease). Phytochemical testing showed the presence of various
Khoula Begum* and Imran Khan
... a product with improved bioactive properties. The research is valuable for understanding the effects of dietary interventions on various biomarkers related to cardiovascular health and metabolic disorders, ultimately contributing to the development of dietary strategies for the prevention and management of cardio-metabolic diseases....
Malik F.H. Ferdosi1, Arshad Javaid2*, Muhammad Samiullah1, Zeeshan Mutahir3 and Tajamal Hussain4
...ers to identify possible bioactive compounds. Twelve compounds were recorded in the methanolic extract with hexadecanoic acid, 15-methyl-, methyl ester as the most abundant ones with 29.78% peak area. Other compounds were linolenic acid methyl ester (15.84%), guaiacol (9.48%), 2-cyclopenten-1-one, 2-hydroxy-3-methyl- (8.56%), 2-cyclopenten-1-one, 3-methyl- (7.73%), butanal, 3-hydroxy- (6.19%), phenol, 4-ethyl- (4.83%), aziridine, 1-(2-methyl-1-propenyl)- (4.50...
Mahmoud Saber Kelany1*; Ehab Aly Beltagy2; Maha Abd El-Fattah Khalil3; Mohamed Ahmed El-Shenawy2; Wagih Abd El-Fattah El-Shouny3
Novel Research in Microbiology Journal (2019), 3(1): 258-270
...; capable of producing a bioactive secondary metabolite. Of the 552 bacterial isolates recovered, only 40 of these isolates exhibited antagonistic activities against different bacterial pathogens. A promising bacterium isolated from Suez bay marine water was identified as Bacillus sp. MH20 using 16S rRNA sequencing, and deposited in GenBank with accession number KM374670. This isolate showed sequence similarity of 88% to B. sonorensis strain NBRC 101234. Well-...
Waithaka, P.N.1*; Mwaura, F.B.1; Wagacha, J.M.1; Gathuru, E.M.2; Githaiga, B.M.2
Novel Research in Microbiology Journal (2019), 3(3): 351-365
...r actinomycetes produced bioactive metabolites. Solid-state fermentation was superior to liquid-state fermentation in recovering the antimicrobial metabolites from the actinomycetes isolates. Molecular identification of the selected isolates needs to be carried out in a future study. Moreover, there is a need to determine the structure of the antimicrobials using nuclear magnetic resonance....
Girma Waktola1; Tasisa Temesgen2*
Novel Research in Microbiology Journal (2020), 4(2): 688-695
...ntains a large number of bioactive components that cause development of its therapeutic functions. The bioactive components that are present in Pleurotus ostreatus mushroom comprise: polysaccharides, lipopolysaccharides, proteins, peptides, glycoproteins, nucle...
Wafa H. Alamshani*; Faisal Al-Sarraj; Mashail A. Algamdi
...
extensive range of bioactive compounds, the diverse parts of this P. granatum plant exhibit
significant pharmacological activities. The bioactive compounds of this plant have been shown
to possess several antioxidants; anti-inflammatory, antimicrobial, anti-diabetic, antiatherosclerotic,
and many other biological effects. Consequently, the purpose of this review
was to hi...
Abeer Muazi Alenazi1; Yasir Anwar1*; Salah E.M. Abo-Aba1; Noor M Bataweel1,2
...or producing a number of bioactive secondary
metabolites, including anti-tumour agents; antibiotics, antifungals, antivirals, anti-hypertension
drugs, and immunosuppressives. In order to compete with other microorganisms, including
those of the same genera, Streptomyces species produce several secondary metabolites.
However, despite the discovery of antibiotics, the infectious diseases remain the secondleading
Ali, A.A.M.1*; Hassanin, M.M.H.2; Abdel-Rahman, T.F.M.2; Mergawy, M.M.3
...ed for
their bioactive components using Gas Chromatography (GC), which were recorded as follows:
linalool and eugenol were detected in basil; terpinen-4-ol, β-phyllandrene, and sabinene in
marjoram oil, and thymol, 1.8-cineole, ρ-cymene, and α-terpinene in thyme oil. In the
greenhouse experiments, Actamyl 70 % wp (wettable powder) and Bio Cure F were the most
effective treatments, which...
Rabaa Yaseen
Novel Research in Microbiology Journal (2020), 4(3): 790-807
...ed to produce antifungal bioactive compounds from agro-wastes using cellulolytic bacteria, and to evaluate their in vitro and in vivo antifungal activities against faba bean damping off disease caused by Rhizoctonia solani. To achieve this purpose, a total of 34 rhizospheric bacterial isolates were screened for their abilities to degrade cellulosic compounds. The bacterial isolate which gave the best cellulolytic activity was identified as Bosea thiooxidans, a...
David C. Nwobodo1,5*; Chibueze P. Ihekwereme2; Chinedu J. Ikem3,5; Festus B.C. Okoye4
Novel Research in Microbiology Journal (2020), 4(3): 845-855
...ar diffusion method. The bioactive components of the fungal extracts were identified using High-Performance Liquid Chromatography-Diode Array Detector (HPLC-DAD) analysis. Three endophytic fungi mainly; Aspergillus sp., Fusarium sp. and Colletotrichum sp. were isolated. At concentration of 1 mg/ml, extracts of the three fungi displayed anti- pseudomonal activities against all the isolates, except for a P. aeruginosa isolate recovered from urine. Results of the...
Simiat O. Jimoh1*; Khadijat O. Adefaye1; Lateefah A. Arowolo2; Ramot B. Badmos-Oladapo1
Novel Research in Microbiology Journal (2022), 6(2): 1530-1542
...h as polysaccharides are bioactive substances obtained from the agricultural feed stocks and\ or crustacean shell wastes, thus chitin biomass as a rich renewable resource; is an additional abundant natural polysaccharide in the environment. Despite the recent interests in the biomedical applications of chitin, complexity of chitosan and their derivatives in terms of controlling their chemical synthesis due to the formation of secondary compounds is a major pro...
Amal Nasser Alahmari1*; Shahira A. Hassoubah1; Bothaina Ali Alaidaroos1
Novel Research in Microbiology Journal (2022), 6(5): 1742-1767
...re abundant producers of bioactive compounds such as secondary metabolites. This mini-review aimed to discuss tens of secondary metabolites of various chemical classes that were generated by a variety of bacterial phyla associated with marine sponges, including Actinobacteria, Proteobacteria, Firmicutes, Bacteroidetes, and Cyanobacteria. Numerous secondary metabolites with antibacterial or antifungal efficacy have been recovered from marine bacteria derived fr...
Amal Nasser Alahmari1*; Shahira A. Hassoubah1; Bothaina Ali Alaidaroos1
Novel Research in Microbiology Journal (2022), 6(5): 1742-1767
...re abundant producers of bioactive compounds such as secondary metabolites. This mini-review aimed to discuss tens of secondary metabolites of various chemical classes that were generated by a variety of bacterial phyla associated with marine sponges, including Actinobacteria, Proteobacteria, Firmicutes, Bacteroidetes, and Cyanobacteria. Numerous secondary metabolites with antibacterial or antifungal efficacy have been recovered from marine bacteria derived fr...
Ghadir A. El-Chaghaby; Heba A. Shehta; Sayed Rashad; El-Shaimaa A. Rawash; Heba R. Eid
Novel Research in Microbiology Journal (2024), 8(1): 2303-2319
... were analyzed for their bioactive components using Gas chromatography-mass spectrometry (GC/MS) and antioxidant properties using different spectrophotometric assays. The detected bioactive components were mainly fatty acids (80 %), flavonoids, terpenoids and caffeine (5.4 %). Spent coffee ethanolic extract was richer in its active components than the aqueous one. Additionally, the in vitro antibacterial efficacy of the extr...
Fateh Merouane1*; Amani Kifadji2; Racha Mansouri3; Meroua Safa Mechouche1,4; Chemes El-Houda Messaad5,6; Anfal Bellebcir1
Novel Research in Microbiology Journal (2024), 8(5): 2555-2579
... as a prolific source of bioactive secondary metabolites, including antimicrobial compounds. In this study, we aimed to optimize the production of anti-MRSA compounds by Streptomyces sp. AR05; a strain isolated from hydrocarbon-contaminated soil, using an integrated approach combining response surface methodology (RSM), artificial neural networks (ANN), and genetic algorithms (GA). The strain was identified through 16S rRNA gene sequencing and exhibited signif...
Mai N. Amer1; Maissara M.K. Elmaghraby2; Aya A.M. Abdellatif2; Sondos R. Salem3; Mariam M. Salama3; Omar A. Abdel Maksoud3; Radwa M. Nasr3; Mohamed N.H. Amer4; Mohamed M.H. Marghany5; Hassan M. Awad1*
Novel Research in Microbiology Journal (2024), 8(5): 2580-2603
...ntion, and production of bioactive compounds. Therefore, modifying the gut microbiota's balance can be highly beneficial for maintaining the human health. Probiotics are live microbial supplements, when consumed with meals; they help the host by harmonizing his/ her intestinal microflora. Supplements containing these good bacteria can be used up, or they can be added to dairy-free or non-dairy foods and drinks. Probiotics are mainly categorized into two main g...
Tran Thi Hong1; Ngo Van Anh1; Nguyen Thi Ngoc Anh2; Nguyen Van Phuong3*
Novel Research in Microbiology Journal (2024), 8(6): 2694-2711
...nd screening significant bioactive compounds such as polyketide synthases, non-ribosomal peptide synthetases, antibiotics, and biocatalysts. The enormous potential of microbial diversity in coastal lagoons remains untapped because of the difficulty of culturing many microorganisms under laboratory conditions. Therefore, this study aimed to decipher the structural and functional diversity of microbial communities, including un-culturable species in lagoon sedim...
Aml Ghanem1,2; Ahmed A. Al-Karmalawy3,4; Noha E. Morsy5; Mahmoud Elsabahy6; Ahmed M. Rayan2,7*
Novel Research in Microbiology Journal (2024), 8(6): 2750-2771
...tential sources of novel bioactive compounds. This study aimed to evaluate the chemical and biological characteristics of Alternaria alternata as an endophytic fungus isolated from Thymus vulgaris. Alternaria alternata was isolated from Thymus vulgaris leaves and characterized using morphological and molecular identification techniques. Chemical characterization of dichloromethane fraction (DCM) of Alternaria alternata was conducted using Liquid Chromatography...
Aulia Kanwal1, Rehana Kausar2, Muhammad Asif Gondal1* and Chi Chen3
...that RH, SB, and CC have bioactive ingredients that positively influenced the growth performance, innate immune response, and hematology of red tilapia. Agricultural by-products are abundant biomass and rich in bioactive and nutraceutical compounds, therefore these are good candidates for maintaining redox balance, health status and growth performance in fish....
Manan Kumar1, Sony Eka Nugraha2*, Nabila Nabila3
...h specific tests for key bioactive compounds: Mayer’s, Dragendorff’s, and Bouchardat’s reagents for alkaloids; hydrochloric acid with magnesium powder for flavonoids; and the foam test for saponins. The Microwave-Assisted Extraction (MAE) method was used to extract compounds from the beetroot tubers. Furthermore, diabetic rats were induced via a single intraperitoneal injection of streptozotocin at a dose of 65 mg/kg body weight (BW), which w...
Mahfouz M.M. Abd-Elgawad
...ence, priming them/their bioactive materials, and introducing additional devices to reform their biocontrol potential....
Merry Muspita Dyah Utami*, Aryanti Candra Dewi, Rosa Tri Hertamawati, Dillenia Jasmine, Nala Wafia, Jini Saputri, Kornelius Hangga Septiyanto
... a chemical composition, bioactive compound, and volatile compound which is suitable as a natural feed additive to improve poultry health and production.
Keywords | Feed additive, Pomegranate, Chemical, Bioactive, Growth promoter
... 
