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Leonard Izzard1, 2, John Stambas1, 2*

...city and immunity and as biomarkers for disease severity.

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Neha Singh and Anjana Pandey

...o discover novel disease biomarkers to facilitate early detection of the disease and for therapeutic purposes.

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G.E. Odo1*, E.J. Agwu1, N.I. Ossai2, C.O. Ezea3, J. Madu1 and V. Eneje2

...tology, oxidative stress biomarkers and biochemistry of African catfish (C. gariepinus) juvenile on days 7, 14, 21 and 28. Fish were exposed to 0.175, 0.0875 and 0.035 mg/L corresponding to 1/10, 1/20 and 1/50 of the 96 h LC50 value (1.75) of the pesticide. Behavioral responses which include colouration of the fish skin and opercula colouration were observed. Aluminium phosphide elicited effects on the haematological parameters of the fish such as a decrease i...
Guang-Xin E1, Yong-Ju Zhao1, Zhong-Yuan Zhang1, Yan-Guo Han1, Wei-Wei Ni1, Ming-Xing Chu2, Yue-Hui Ma2, Jian-Ning He3, Huai-Zhi Jiang4, Jia-Hua Zhang1, Zhong-Quan Zhao1, Yan Zeng1, Ri-Su Na1, Gao-Fu Wang5, Hang-Xing Ren5 and Yong-Fu Huang1*
...ites are not appropriate biomarkers for goat breeding.

 

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Soraya Khosravian Dehordi*, Abdolnaser Mohebbi and Kahin Shahanipour

...(nano-Se) influencing on biomarkers of oxidative status in the rats spleen exposed to the cadmium (Cd) metal. For this purpose, thirty male rats equally divided into six groups, group I received nano-Se (0.1mg/kg) alone as dose, group II selenite odium (0.1mg Se/kg) alone, group III Cd chloride (300mg/250cc), group IV Cd along with nano-Se, group V Cd along with selenite sodium and group VI (control) given (1 ml) saline. All doses was orally (gavage) given to ...
Naimat Ullah1,3,*, Aneela Zameer Durrani1, Muhammad Avais1, Nisar Ahmad2, Sana Ullah3, Muhammad Shuaib Khan3, Khalid Mehmood5, Mumtaz Ali Khan1 and Ikramul Haq1
...us risk factors and host biomarkers concerned with the occurrence of theileriosis in sheep. Total 600 blood samples were taken each 200 from districts Bannu, Tank and Dera Ismail Khan of southern Khyber Pakhtunkhwa Pakistan and screened through blood microscopy. The current study revealed an overall prevalence of ovine theileriosis as 27.5%, 13% and 19.5% in districts of Dera Ismail Khan, Tank and Bannu, respectively. Sex, tick infestation, animal keeping cond...
Ayesha Noreen1, Dilara A. Bukhari2 and Abdul Rehman1,*
...l for the development of biomarkers and therapeutic strategies. The objective of this review was to summarize the roles of ROS in different stages of cancer, cell invasion, angiogenesis and metastasis.
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Muhammad Zahid1, Aneela ZameerDurrani1, Muhammad Ijaz1, KhushiMuhammad1,Muhammad Usman1,*, Muhammad Husnain1 and Nadeem Kamal2

 

...on the basis of clinical biomarkers. Blood and mosquito samples were collected. Blood samples were processed through complement fixation test and RT-PCR, while mosquito samples were processed through RT-PCR. Overall prevalence of bovine ephemeral fever (BEF) in indigenous breeds of bovine was 63.33%, lower, than exotic breeds 64.66% which were found to be more prone to disease. In the case of buffalo breeds, prevalence was more in Nili Ravi buffalo, i.e.

Riffat Mehboob1*, Sami Ullah Mumtaz2, Zoya Manzoor3, Sajid Abaidullah2, Fridoon Jawad Ahmad1

Deranged biochemical and hematological profile of septicemia patients in Mayo hospital, Lahore
...e possible role of serum biomarkers of liver, kidney and blood in the diagnosis of septicemia. 101 confirmed patients of septicemia from a tertiary care hospital in Lahore were included. Liver and renal function tests were performed for all patients. Patients were divided into 3 age groups on the basis of age: 30-50, 51-70 and 71-90 years. In Liver function Tests, ALT (37.62%), AST (50.49%) and ALP (99%) were elevated, Bilirubin was normal in majority of patie...
Fariha Latif* and Muhammad Javed
...tion due to their use as biomarkers to assess contaminants impact on fish at earlier level of exposure. Fish from different species has diverse ecological needs and respond differently to the environmental stress conditions. Thus, the sensitivity, bioaccumulation and antioxidant capacities of three major carps Catla catla, Labeo rohita and Cirrhina mrigala towards metals mixture (Cd+Cr+Cu+Pb) were determined during present research work. S...

 Jawaria Shaheen1, Samiah Shahid1, Sabahat Shahzadi2, M. Waheed Akhtar1,3 and Saima Sadaf1,*

...iagnostic and prognostic biomarkers specifically for TNBC. The blood samples were collected from 37 TNBC diagnosed patients and 34 age-matched non-TNBC controls to investigate the expression of miRNA panel. Plasma was isolated by standard protocol of centrifugation and then isolation of total RNA including miRNA was done. About 100ng of isolated miRNA was converted to cDNA after addition of poly (A) tailing and then expression profiling was done by using real ...
Mumtaz Ali Khan1, Aneela Zameer Durrani1, Sher Bahadar Khan2, Naimat Ullah Khan3, Muhammad Asfandyar Khan2, Kashif Prince1,*, Mahboob Ali1, Ghazunfar Rashid1 and Azmat Ulah Khan2
Hafiz Muhammad Arsalan1, Maria Altaf1, Zeemal Seemab Amin1, Muhammad Khalil Ahmad Khan2, Anum Shahzadi1, Hina Mudasser1, Iqra Maqsood1, Nazia Gulshan1, Saira Naseem3
Mehwish Faheem1*, Maleeha Rafeeq1, Aisha Majeed1 and Saba Khaliq2
... proteins may be used as biomarkers to assess the presence of BPA in the environment. 
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Haq Aman Ullah1,*, Aneela Zameer Durrani2, Muhammad Ijaz2, Aqeel Javeed3, Muqadder Shah1 and Ikramul Haq1
... (AFB1) on physiological biomarkers with special reference to udder health and serum parameters of lactating goats. Thirty two lactating Beetal goats of 3-4 y age, weighing 40.91±0.285, were randomly selected, and equally divided into four groups. Group A was kept as control while animals of groups B, C, and D were individually fed daily with 30µg, 40µg and 50µg of AFB1, respectively, through naturally contaminated cotton seed cake for...
Fariha Latif1*, Muhammad Javed2, Hammad Ahmad Khan2 and Khalil-Ur-Rehman3
...f antioxidant enzymes as biomarkers of oxidative stress in the bio-monitoring of aquatic pollution.
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Saman Muhsin Abdulkareem* and Nadir Mustafa Nanakali
...evel of oxidative stress biomarkers, liver enzymes, and the expression of CYP1A1 gene. The results of this study indicated that exposure to TCDD (10µg/kg/day) could significantly increase liver oxidative stress biomarkers and serum liver enzymes (p<0.05). While, pre and post treatment of QCT (20 mg/kg/day) had protective effects on hepatotoxicity induced by TCDD and could significantly decrease these factors ...
Hui-Ying Chen1,2*, Ping-Chuan Yin1,2, Ya-Nan Lu1,2, Hai-Yun Li1,2*and Yang Shan3
...dentify potential future biomarkers.
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Shaista Abbas1,Imtiaz Rabbani1, Hafsa Zaneb2, M. Shahbaz Yousaf1, Saima Ashraf2, Abid Hussain Shahzad3, M. Afzal Rashid4 and Habib Rehman1,*
...ht (BW) and serum health biomarkers in Beetal goats during the transition period. Twenty-four Beetal goats were randomly allotted to three groups YSC0, YSC5 and YSC10 and were fed a basal diet supplemented with 0g, 5g or 10g yeast day/animal, respectively for 4 weeks before and -4 weeks after kidding. When compared with the non-supplemented goats, dietary yeast improved (P<0.05) DMI during transition period however, BCS (P = 0.81) and BW (P = 0.59) did not ...
Tehreem Usman1, Sajid Abdullah1, Huma Naz2*, Khalid Abbas1, Laiba Shafique3 and Qaisra Siddique1
... to fish and response of biomarkers depends on the type of toxicants and exposure duration.
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Mumtaz Ali Khan1, Sher Bahadar Khan2, Shakoor Ahmad2, Irshad Ahmad3, Kashif Prince1*, Ghazunfar Rashid1, Mahboob Ali1, Imdad Ullah Khan4Asad Ullah5, Naimat Ullah4, Muhammad Shoaib2 and Said Sajjad Ali Shah2
... different physiological biomarkers in Clostridium perfringens (CP) infections in Balkhi breed of sheep in Khyber Pakhtunkhwa, Pakistan. Study was conducted on 184 sheep suspected of having enterotoxemia and 107 sheep were identified to be infected with Clostridium perfringens. Genotypic Analysis of all isolates from infected sheep was performed. Results showed, 53.27% isolates showed infection of CP type A, 10.28% of type B and 36.44% of ...

Aliya Munir1, Sajid Abdullah1*, Huma Naz2*, Khalid Abbas1, Tanveer Ahmed3 and Zahid Farooq2

...pecies. Oxidative stress biomarkers like antioxidants enzymes have been successfully used in ecotoxicology field for evaluating the stress response of organisms exposed to pollutants. Therefore, this work was designed to evaluate the peroxidase (POx) level in kiney, gills and liver of fish Channa striata exposed to LC50 concentration (1.374µgL-1) of deltamethrin+endosulfan (DM+ES) mixture for 4-day. Sampling was performed after a 24-hr period. Fish were ...

Sajid Abdullah1*, Huma Naz2*, Zunera Abbas1, Uzma Nazir1, Mehrunisa Basharat1, Tanveer Ahmed3, Adnan Ahmad Qazi2

...ic ecosystems using fish biomarkers
 
Novelty Statement | The study is novel for detecting the genetic damage at cellular level of fish (Wallago attu) caused by heavy metals and industrial toxicants in water.
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Muhammad Zahid1, Aneela Zameer Durrani1, Muhammad Ijaz1, Khushi Muhammad2,Muhammad Usman1,*, Muhammad Husnain1 and Nadeem Kamal3
...on the basis of clinical biomarkers. A comparative analysis of physiological biomarkers was also made. For this experimental study 30 BEF positive cattle at their first lactation were selected and equally divided into three groups A, B, and C. A fourth group “D” comprising 10 healthy cattle was made as positive control while group C was negative control. The animals in group A were treated with antibiotic (fluore...

Heba El-Zahar*, Zeinab Abd El-Rahman, Abbas El-Naggar 

...an values of IBD-related biomarkers (CRP, haptoglobin, and fecal calprotectin concentrations) increased significantly (p<0.05 or p<0.01) compared to controls. CRP, haptoglobin concentrations, and fecal calprotectin were found to have a strong positive correlation. Furthermore, blood enzymes, glucose and electrolytes were significantly correlated with CRP as an IBD-related biomarker. It is concluded that, hematological indices such as total leukocyte coun...

Safaa M. Barghash1*, Amani A. Hafez2

...ession, were assessed as biomarkers of the clinical phase of infections. Results revealed that T. evansi infection has a significant influence on the performance of rats, and antibody responses against both vaccines were significantly reduced in T. evansi-infected groups compared to controls and others did not contain T. evansi. It was accompanied by significant elevations levels in total leukocytic counts, urea, ALT, AST, ALP, and the total protein compared t...

Uzma Jabeen1, Asmat Salim2*, Irfan Khan2, Nadia Naeem3 and Rubina Mushtaq4

...ression of kidney injury biomarkers, kidney injury molecule-1 (KIM-1) and osteopontin (OPN), while the effect of DOX was also analyzed in terms of changes in the anti-inflammatory cytokine, interleukin-10 (IL10). Of the oxidative stress induced genes analyzed, the expression of Gpx1 was found to be increased significantly. Significant increase was also observed in case of IL10 gene, while kidney injury biomarker level was not increased in response to DOX. It i...

Muhammad Zahid Iqbal1, Aneela Zameer Durrani1, Jawaria Ali Khan1, Nisar Ahmad2, Muhammad Usman1,*, Abdul Jabbar1, Saba Usman3, Ahsan Anjum3, Muhammad Husnain1, Nadeem Raza1 and Anwar-ul-Haq4

...ion of selected clinical biomarkers was also ascertained and all of these were found significantly (p<0.05) associated with the incidence of coxiellosis. The results of animal-related risk factors indicated that with increasing age and parity number, poor BCS, or a history of disease, the incidence of coxiellosis became significantly (p<0.05) higher. Various farm-related risk factors were also found significantly (p<0.05) associated with Coxiellosis. ...

Hye-myoung, Jang 1,3, Ju-Hyeun, Kim3, Garam Park1, Yoon Dong Choi4, Sun-Eui Kim1,5, Gwang Joo Jeon1,2* 

... inhibition of two major biomarkers of beta-amyloid (Aβ) and tau-protein (τ-protein) formed in the brain tissues. Under the hypothesis of obesity inducing potential dementia, mice were fed with high-fat energy diet to gain excessive weight. The experimental groups in this study are 1) high-fat diet fed only (control) and 2) high-fat diet fed with AE added (AE group). After the experiment was terminated, they were slaughtered and brains were obtained. ...

Asim Faraz1, Muhammad Yaqoob2, Nasir Ali Tauqir3, Hafiz Muhammad Ishaq1, Ayman Balla Mustafa4, Amir Ismail5, Muhammad Arslan Akbar6, Abdul Waheed1* and Muhammad Shahid Nabeel7

...designed to use hormonal biomarkers in terms of progesterone and estradiol as early pregnancy indicators in female dromedary camel. A total of 44 female Marecha camels were selected in Thal desert of Pakistan during breeding season (December-March) and kept under semi-intensive management system (SIMS). Selected animals were divided into two comparable groups of 22 animals in each to determine the hormonal profile. G1 was composed on lactating non-pregnant whi...

Harpreet Kaur* and S.S. Hundal

...en reported as potential biomarkers to assess toxicity levels, hence the activity of these enzymes were assessed to study imidacloprid toxicity. Inhibition of AChE activity was observed in both the earthworm species in all the doses of imidacloprid, indicating neurotoxicity. There was an initial increase in the GST activity followed by its decrease with the duration of exposure to imidacloprid. Imidacloprid is highly toxic to earthworm inducing physiological w...
Muhammad Kashif Iqbal1*, Khalid Mehmood2,4, Shakeel Ahmed3, Fazul Nabi4, Muhammad Arif Rizwan1, Muhammad Kaleem1, Mushtaq Ahmed1, Abdul Waheed1 and Jiakui Li5
... (SOD; GSH-Px) and serum biomarkers and the protective effects of the medicine was assessed through these values. Results showed that VEGF mRNA levels were significantly (P<0.05) up-regulated; however, the Flk-1 receptor levels were down-regulated in TD-affected birds significantly (P< 0.05) as compared with the control group. Furthermore, thiram induction also increased the levels of AST, ALT and MDA contents in liver, whereas decreased the antioxidant ...

Mohammed A. Almujtaba1, Turky Omar Asar2, Salma Naqvi3, Vikas Kumar4, Fahad A. Al-Abbasi1, Abdulbasit I. Al-Sieni1 and Firoz Anwar1*

... Serum levels of cardiac biomarkers, CRP, Fibrinogen, BUN and creatinine increased, while zinc, IL-10 and angiotensin levels decreased significantly in DC as compared to NC. Interestingly, renin level also decreased in DC group. Heart tissues from each group were examined for histological changes. Altered serum levels of the biomarkers were restored on treatment with Zamzam water. Histopathological studies are in agreement w...
Muhammad Sajid Hamid Akash1*, Hina Sharif1, Kanwal Rehman2, Sumbal Rasheed1 and Shagufta Kamal3
...levels of glycemic index biomarkers and carbohydrate metabolizing enzymes. Simultaneously, we also measured arsenic concentration in liver using HG-AAS technique. ATO exposed rats showed a significant elevation in serum glucose, reduction in serum insulin, rise in insulin resistance and alteration of carbohydrate metabolizing biomarkers when compared with unexposed rats. Arsenic concentration was found to be significantly hi...

Florence N. Nworah*, Nene O. Uchendu, Ifeoma F. Chukwuma*, Emmanuel C. Ossai and Emmanuel C. Ezeako

...ties of oxidative stress biomarkers. However, treatment with the blood of P. sinuatus reversed the effect of cyclophosphamide on the haematological parameters and the oxidative stress biomarkers. These results suggest that the P. sinuatus blood exhibits both haematopoietic and antioxidative potential and could be a good source for the amelioration of leucopenia and anaemia.

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Shahrokh Mojarradgandoukmolla* and Hasan Akan
...ion tests, and oxidative biomarkers were measured. Histological evaluation was also performed. Among the hematological parameters in the treated groups, only lymphocytes showed a significant change in the treated group with T. uncinata. The levels of liver enzymes, lipid profile and glucose in the ethanol group increased significantly compared to the control, while these parameters were significantly improved in the groups treated with these three taxa....
Jawad Ahmad1, Huang Yun-He2, Arab Hussain1, Amjadullah1, Ahmad Yar1, Subhanullah1, Zeshan Ali1, Hamid Sattar3, Tariq Hussain3, Hamayun Khan3, Ali Gohar6, Obaidullah4, Nan Zhu Fang5, Yanya Fang5, Ihsan Ali3* and Zhongshu Li5,*
...changes in hematological biomarkers of Achi cows at different stages of pregnancy. Forty multiparous cows with 4 ± 1 years of age and live weight of 188.23 ± 2.6 to 207.13 ± 2.59 kg of different stages of pregnancy were divided into four groups (Group1=1sttrimester Group 2= 2ndtrimester and Group 3= 3rd trimester, Group 4= non-pregnant). Blood samples were collected from all the animals and assayed for hematological <...

Eman S Ramadan, Mohamed E Ali, Mohamed A Elkhiat 

...gnostic value and stable biomarkers for liver injury detection in cats.
 
Keywords | Feline infectious peritonitis, MicroRNR-122, ALT, Biochemistry, Ultrasonography
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Esam A Razin1, Hassan Sobhy2, Tarek R. AboElnaga1, Asmaa A. Darwish1*, Rasha S. Mohammed1

...LDH, and GR are moderate biomarkers for disease diagnosis and its treatment monitoring. 
 
Keywords | Anti-trypanosomal activity, Basil extract, Clinicopathological alterations, Histopathological alterations, Diminazene aceturate
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Ghada A. Ibrahim1*, Mohamed Sayed Helal1, Nahed Abd Elhafeeze Kamoura2, Mohamed Samir3,4, Amira Mohamed Mazid5, Mohamed F.M. Farag6

...d cattle could be act as biomarkers for bacterial infections.
 
Keywords | Klebsiella spp, ESBL, Heamato-biochemical; antibiotics, MDR, Virulence, Resistant, Hemobiogram, Leucogram, Cattle farms
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Asmaa A. Darwish*, Mona A. Mahmoud, Adel M. El-Kattan 

... combined) are excellent biomarkers for ovine and caprine brucellosis.

Keywords | Brucellosis, Clinicopathological alterations, Matrix metalloproteinases, New biomarkers, Seroprevallance 

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Muhammad Shahid1*, Muhammad Idrees1, Afza Rasul2, Iram Amin1 and Samia Afzal1

...cs were used to find the biomarkers of infection. Logistic regression analysis revealed that liver enzymes (ALT, AST, ALP, γGT, albumin), blood cell count (globulin, platelets, MCHC RBC, WBC, monocytes% and lymphocytes%), lipid profile (HDL, LDL, VLDL, TC) were significant predictive factors in HCV infection. Similarly, ROC analysis suggested that ALT, AST, ALP, MCHC, TC, and VLDL variables have the potential to discriminate HCV infection from healthy in...

Nawfal Hammadi Jasim1, Yasmeen Jassim Mohammed2 , Jala Amir Salman Alahmed1, Majdy Faisal Majeed3* 

Asmaa A. Darwish*, Adel M. El-Kattan, Mona A. Mahmoud, Mohamed T. Ragab, Amani A. Hafez 

...erence to their value as biomarkers for the disease. Vaginal swabs were collected from 110 ewes and 150 does for bacteriological examination. Blood samples were collected for immunological, hormonal, and iron profile estimation. The total recovery of B. melitensis was 13.50% with nearly equal percentages in sheep (13.60%), and goat (13.33%). B. melitensis isolates had bvfA gene, virB gene, and ure gene with percentages of 62.8%, 77%, and 37% respectively. B. m...

Lu Xie1,2,3,4,5, Ye Gu1,2,3,4, Qiang Liu1,2,3,4, Hongzhang Shen1,2,3,4, Yifeng Zhou1,2,3,4, Jiangfeng Yang1,2,3,4, Xiaofeng Zhang1,2,3,4* and Jinyu Huang1,5*

...c targets and prognostic biomarkers in hepatocellular carcinoma.

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Munir Ahmad1, Abdul Ghaffar1, Riaz Hussain2* and Rifat Ullah Khan3*

...ver biochemical profile, biomarkers of kidneys, triglyceride, glucose, and cholesterol in fish treated with pesticide. Histopathological examination showed renal tubular degeneration, widening of Bowman’s space and necrosis in kidneys. Different histopathological lesions in liver of treated test specimens including edema, hemorrhages, atrophy of hepatocyte and hepatocyte having eccentric nuclei. In the brain, different histological alterations like necro...

Dalia M. Amin1*, Noha Mohammed Halloull1, Walaa E. Omar2, Basma A. Ibrahim2, Nahla M. Ibrahim1 

...bsp;adenine. Antioxidant biomarkers and renal function tests were evaluated. Histopathological scoring of tubular damage and renal fibrosis as well as immunohistochemistry evaluation of Bcl2 and p53 expression in the kidneys were performed. In renal tissue, the concentrations of transforming growth factor-1, pERK1/2, and pSTAT3 were assessed. Results: The group that received adenine treatment had considerably higher blood urea nitrogen and serum creatinine lev...

Aneela Ahmed Tagar1*, Mahvish J. Channa2, Kanwal Ahmed Tagar3 and Kaka Kainat4

... among survivors through biomarkers and to assess the impacts of post infections on human health including the malnutrition and mental health of patients. The study was conducted in the civil hospital Hyderabad and LUMHS Jamshoro. A total number of 65 post-COVID-19 patients were selected for the study with negative RT PCR tests. A questionnaire was filled after taking consent of patients whereas blood samples were collected to detect the ...

Kazi Afsana Homayra Orchy1, Mst. Antora Akter1, Nelema Yesmin1, Md. Moshiur Rahman Khan1, Marzia Rahman2, Md. Mahmudul Alam1* 

...ALP) and kidney function biomarkers (creatinine, BUN) showed a significant increase in burn patients of the saline-treated control animals, whereas, the animals treated with hPRP exhibited the normal range of these functional biomarkers. On the basis of morphology, histopathology, and biochemical analysis, it can be concluded that PRP, irrelevant of source improves and accelerates the burn wound healing with no adverse effec...

Hafiz Muhammad Arsalan1, Amina Arif1 and Muhammad Khalil Ahmad Khan2*

...as observed. Antioxidant biomarkers i.e. MDA, SOD and CAT were augmented in control group as compared to CML treated groups. Decreased GSH level was reporetd in the CML group while increased in the nilotinib treated group compared to the Imatinib treated group. Other stress markers i.e. NO, AGEs and AOPP were also found to be high in level in control group compared to CML treated group. Micronutrient i.e. retinol, ascorbic acid, alpha tocopherol were increased...

Tahir Rasool Qamar1, Sanaullah Iqbal1*, Muhammad Nasir1 and Habib-ur- Rehman2

...ctive impact against CRC biomarkers particularly if it is taken as preventive measure.

 
*      Corresponding author: [email protected]
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Tehreem Iqbal1, Roheela Yasmeen1* and Faheem Hafeez2

...eatinine, and Uric acid) biomarkers were assessed. The highest levels of ALT and ALP were linked to liver injury and a higher weight in the liver were observed in BPA treated rats as compared to the control group. Similarly, an increase in blood parameters were recorded in BPA treated rats followed by post -treated rats and pre- treated group. It was concluded by the study that BPA have pronounced adverse effects in the exposed animals particularly in BPA and ...

Asmaa A Darwish* 

... IL-1β are reliable biomarkers for urine retention in sheep while, IL-1α, TNF-α, Fb, and ferritin are better for urethral process resection outcomes prediction.
 

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Mustafa M. Khalaf*, Rana A. Salih 

...ndialdehyde (MDA), liver biomarkers (ALT, AST, ALP, and TP), and prothrombin time. Otherwise, glutathione (GSH), and total protein (TP) level was substantially reduced in the control group. Studies have demonstrated quercetin’s capacity to decrease cyclophosphamide’s effects on (MDA, ALT, ALP, TP, and AST) while increasing GSH. Also, quercetin significantly affects body weight for their group and mixed group with cyclophosphamide. The results ...

SADAF IFTIKHAR1, SAMAN SHAHID2*, MUHAMMAD UMAR HASSAN1 & UBAID ULLAH3

...ehydrogenase) as primary biomarkers in diagnosing the COVID-19-associated coagulopathy (CAC) in severe and critical cases. 141 COVID-19 patients of severe and critical categories, were enrolled from an epicenter tertiary care hospital. The mean values of platelets were found normal, whereas, the mean values of LDH were found elevated in both severe and critical cases. There was no patient with low value of LDH in both groups. 87% patients were having high valu...
Qingsen Ran1,2, Manjing Li3, Jiayin Han3, Lifang Wang3, Han Wang3,4, Shaobo Liu5* and Yanping Wang1*
...">Identification of core biomarkers for cancer prevention and treatment is crucial. Tumor glycolysis is an important metabolic phenotype and many natural compounds from medicinal plants exhibit anti-glycation effects. Therefore, it is of potential significant to find biomarkers based on glycolysis-related genes in predicting the prognosis of colon cancer (CC), a common invasive gastrointestinal tumor. In this study, clinical...
Muhammad Javed Iqbal1, Farah Rauf Shakoori1*, Bushra Muneer2 and Abdul Rauf Shakoori3
...c gene mutation (genetic biomarkers) provides the guideline to use a specific drug in a specific dose for a specific patient. The PI3K/AKT1/MTOR (PI3K) pathway is crucial for normal cellular processes. Several activating factors and genetic mutations, in associated genes (PIK3CA, AKT1, MTOR and PTEN), lead this pathway to function abnormally to trigger breast cancer. The mutations in these genes were explored in female patients with breast cancer. The demograp...

Muhammad Usman1*, Aneela Zameer Durrani1, Nasir Mehmood2, Muhammad Hassan Saleem1 and Mamoona Chaudhry3

...ilability. Five clinical biomarkers including fever, anorexia, arthritis, lameness, and lymphadenopathy were used to declare the status of the disease at days zero, 7th, 14th, 21st, and 28th. Serum samples were also collected on the same days for determining C-reactive protein (CRP) values. The results of clinical biomarkers showed that doxycycline cured the dogs immediately when checked on the 7th day followed by amoxicilli...

Huma Naz1*, Sajid Abdullah2, Tanveer Ahmed3*, Khalid Abbas2, Syed Qaswar Ali Shah1, Muhammad Rizwan1, Fareeha Latif4, Adnan Ahmad Qazi1, Muhammad Adeel Hassan5

...et and MN Assay are good biomarkers to identify the insecticides pollution. The results of our study can be utilized in environmental risk evaluation and in bio-monitoring approaches. 
 
Novelty Statement | This research sheds light on the genotoxicity and environmental risks associated with endosulfan and chlorpyrifos pesticides in freshwater ecosystems and offers new insights into the potential synergistic effects of these p...

Sri Purwanti1*, Wempie Pakiding1, Marhamah Nadir1, Nurhayu2, Kusumandari Indah Prahesti1, Sitti Nurani Sirajuddin1, Jasmal Ahmari Syamsu1,4, Andi Mushawwir3 

...ation and cardiovascular biomarkers of native chickens given a combination of maggot, indigofera and turmeric. A total of 120, 4-week-old male indigenous native chickens with an average initial weight of 42-45 g were divided into 3 treatment groups and fed diets, namely P0 (basal feed), P1 (basal feed + maggot mash 25%+ indigofera mash 5%+ turmeric mash 2.5%), and P2 (basal feed + maggot mash 20% + indigofera mash 10% + turmeric mash 2.5%). The result of this ...

Asad Sultan1, Ziaul Islam2*, Faiza Shahzadi3, Sarzamin Khan1, Rafiullah Khan1 and Ihsan Ali4

...ls of lipid peroxidation biomarkers, without a harmful effect on liver and kidney function. In conclusion, the use of natural additives is necessary to improve growth performance, and nutrient digestibility, decrease nitrogen losses, feed cost, and environmental pollution.

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Naveed Hussain1*, Muhammad Arif Khan1, Asim Khalid Mahmood2, Muhammad Yasin Tipu3, Mamoona Chaudhry4, Hamad Bin Rashid1, Haroon Akbar5 and Abdul Aziz6
...gy, serum analysis, bone biomarkers, mechanical assessment, radiographic evaluation and histomorphometry. We concluded that Bone-BMA combination showed best results in fracture healing and bone remodeling while Bone-PRP combination was below par than Bone-BMA but was superior to Bone-DFS combination. More clinical research may be required before widespread use of these regimens. Furthermore, it is paramount that veterinary orthopedic surgeons must have contemp...

Lei Chu1, Jie Yang2, Zhenshi Chen2, Xiajun Zhang1, Weidong Wu3*, Shaoru Zhang2 and Lihui Wang2*

...CM2 and GINS2 may be new biomarkers to predict the prognosis of CC.

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Hawraa F.H. Alowaid1*, Afrah Adil Hassan1, Majdy Faisal Majeed2

...sfunction in the studied biomarkers compared to the other groups. Prolonged tramadol use carries a risk of greater hepatic and renal damage. As such, tramadol’s harmful effects must be taken into account during ongoing treatment.
 
Keywords | Tramadol, Functional, Histopathology, Oxidative stress, Antioxidants, Biochemical indices, Liver, Kidney, Rat
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Tahani Ahmad Al-Matrafi1, Zuhair M. Mohammedsaleh2, Mamdoh S. Moawadh2, Waheeb S. Aggad3, Rawabi Mohamed almuhimed4, Zamzam Alhuwaymil5, Aishah E Albalawi6, Ifat Alsharif7, Hailah M. Almohaimeed8, Fatima S. Alaryani9 and Mona H. Soliman10,11*

..., along with other liver biomarkers. Histopathological alterations in the liver were evaluated using Hematoxylin and Eosin staining. The leaf extracts effectively restored liver function indicators and hepatic antioxidants to normal levels, demonstrating a significant improvement compared to the elevated levels observed in the paracetamol control group (P < 0.001). Furthermore, a reversal of hepatoarchitecture was recorded. The study highlights the pronounc...

Saima Naz1*, Moazama Batool2*, Qurat Ul Ain2, Ahmad Manan Mustafa Chatha3, Sheeza Bano2, Sadia Nazir4, Ghulam Abbas5 and Unab Zahra1

...e fish serve as valuable biomarkers for ecological harm caused by toxins, especially as they are a significant source of protein and easily accessible. The current study focuses on histopathological alterations, nuclear changes in erythrocytes, and DNA damage in fish brain after exposure to Malathion at environmentally relevant concentrations. The research aimed to assess the potential toxicity of Malathion on fish health, utilizing histological examinations a...

Nesreen Ahmed Nasser1, Anas H. Sadek2, Bayadir Abdulhussein Mahmeed3, Osama Akram Mohsein4* 

...ons; The increase in all biomarkers in patients with prostate cancer suggests the importance of intensifying studies on this type of cancer because of its future risks. 

...

Kremlin Mark B. Ampode1,2,3*, Ramanathan Solaiyappan1, Baskaralingam Vaseeharan1 

...d in various antioxidant biomarkers (P<0.05). Superoxide dismutase (SOD) enzyme activities in the gills showed significant enhancement (P=0.008), whereas no significant change was detected in the liver (P=0.088). Catalase (CAT) enzyme activities significantly increased in the gills and liver (P=0.001). Additionally, glutathione S-transferase (GST) activity was significantly elevated in both the gills and liver (P=0.006). Neurotoxicity assessment through ace...

Suroor Hafedth Mohammed, Tahreer Mohammed Al-Thuwaini* 

... with the adipose tissue biomarkers in Awassi ewes. In the current study, 100 sexually mature, not pregnant or lactating, and healthy ewes between the ages of 3 and 4 years were evaluated. The live body weight and age of each animal were determined. Serum was collected to measure leptin and visfatin hormones using ELISA kits made by SunLong Biotech. This study revealed that litter size significantly (P ≤ 0.05) influences the live body weight and adipose tis...

Saher Mahmood Jwad1, Tamadhur Hani Hussein2, Tahreer Mohammed Al-Thuwaini2* 

...ble alterations in these biomarkers when compared with the control group. According to the findings of the current study, broccoli aqueous extract exerted potent protective activities on the thyroid and hepatic tissues, as well as ameliorated their functions. Furthermore, it inhibited or reduced the oxidative damage induced by paracetamol probably due to its biologically effective ingredients, particularly the strong antioxidants. 

...

Ashraf B. Said*, Ibrahim A. Ibrahim, Hoda I. Bahr, Marwa A. El-Beltagy

...decrease in inflammatory biomarkers levels and tissue expressions, especially GLP-1 and Stem cell groups combined with metformin. The study concluded that whether BM stem cells or GLP-1 able to decline hyperglycemia and inflammatory conditions associated with diabetes and have additive or even synergistic effects with metformin in alleviating T2DM complications.
 
Keywords: BM stem cells, GLP-1, Type II diabetes, Inflammation
...

Hakeem Jawad Kadhim1, Abbas Kamil Shlaga1*, Safaa Hussein Ali2 

... of NDV and inflammatory biomarkers, including C-reactive protein (CRP), interleukin 6 (IL-6), interleukin-1 beta (IL-1β), and gamma interferon (IFN-γ) genes were analyzed. There were ninety birds used in the study; sixty samples were collected from infected flocks and assigned as an infected group, while thirty samples were gathered from healthy (uninfected) flocks and considered as a control group. Samples, including blood, liver, and tracheal swa...

Abdul Ghaffar1*, Maria Niaz1, Ghulam Abbas2, Riaz Hussain3, Fozia Afzal4, Habiba Jamil1, Ahrar Khan5,6, Rabia Tahir7, Muhammad Ahmad Chishti1, Shahnaz Rashid3, Shahzad Ali Gill8, Aliya Noreen9, Ayesha Maqsood1 and Kashfa Akram1

Sarhad Journal of Agriculture

December

Pakistan J. Zool., Vol. 56, Iss. 6, pp. 2501-3000

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